Q96SB4: SRSF protein kinase 1
Protein names | - SRSF protein kinase 1 - 2.7.11.1 - SFRS protein kinase 1 - Serine/arginine-rich protein-specific kinase 1 - SR-protein-specific kinase 1 |
---|---|
Gene names | SRPK1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q96SB4 |
14
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN
70 80 90 100 110 120
DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET
130 140 150 160 170 180
ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN
190 200 210 220 230 240
YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR
250 260 270 280 290 300
SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ
310 320 330 340 350 360
KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI
370 380 390 400 410 420
EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE
430 440 450 460 470 480
VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV
490 500 510 520 530 540
NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM
550 560 570 580 590 600
AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI
610 620 630 640 650
TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS
Isoforms
- Isoform 1 of SRSF protein kinase 1 - Isoform 3 of SRSF protein kinase 1Sequence View
10 20 30 40 50 60
MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN
70 80 90 100 110 120
DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET
130 140 150 160 170 180
ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN
190 200 210 220 230 240
YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR
250 260 270 280 290 300
SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ
310 320 330 340 350 360
KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI
370 380 390 400 410 420
EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE
430 440 450 460 470 480
VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV
490 500 510 520 530 540
NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM
550 560 570 580 590 600
AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI
610 620 630 640 650
TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS
10 20 30 40 50 60
MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN
70 80 90 100 110 120
DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET
130 140 150 160 170 180
ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN
190 200 210 220 230 240
YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR
250 260 270 280 290 300
SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ
310 320 330 340 350 360
KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI
370 380 390 400 410 420
EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE
430 440 450 460 470 480
VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV
490 500 510 520 530 540
NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM
550 560 570 580 590 600
AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI
610 620 630 640 650
TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS
Protein Neighborhood
Domains & Features
14 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q96SB4-1-unknown | MERKVL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q96SB4-24-unknown | RKSETQ... | 24 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13119 | |||
Q96SB4-24-unknown | RKSETQ... | 24 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146423 | |||
Q96SB4-249-unknown | SAVSTA... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169007 | |||
Q96SB4-249- | SAVSTA... | 249 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q96SB4-249- | SAVSTA... | 249 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q96SB4-249- | SAVSTA... | 249 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q96SB4-249- | SAVSTA... | 249 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q96SB4-357-unknown | NGVIEV... | 357 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13121 | |||
Q96SB4-357-unknown | NGVIEV... | 357 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153724 | |||
Q96SB4-420-unknown | EVSDTM... | 420 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q96SB4-420-unknown | EVSDTM... | 420 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162158 | |||
Q96SB4-429-unknown | SSSTVG... | 429 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166885 | |||
Q96SB4-429- | SSSTVG... | 429 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q96SB4-429- | SSSTVG... | 429 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q96SB4-435-unknown | QSFSEQ... | 435 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166887 | |||
Q96SB4-435- | QSFSEQ... | 435 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q96SB4-436- | SFSEQH... | 436 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q96SB4-436- | SFSEQH... | 436 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q96SB4-436-unknown | SFSEQH... | 436 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14872 | |||
Q96SB4-436-unknown | SFSEQH... | 436 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154685 | |||
Q96SB4-438-unknown | SEQHIS... | 438 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166889 | |||
Q96SB4-438- | SEQHIS... | 438 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q96SB4-438- | SEQHIS... | 438 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KDKAQR | 23 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13119 | |||
...AEINCN | 356 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13121 | |||
...AEINCN | 356 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137147 | |||
...STVGQS | 435 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14872 | |||
...STVGQS | 435 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138110 | |||
...PWLNS | 655 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PWLNS | 655 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt86310 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 23 | KAQR.|.RKSE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 356 | INCN.|.NGVI | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAM_HUMAN | 435 | VGQS.|.SFSE | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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