Q96T37: RNA-binding protein 15 {ECO:0000305}

General Information

Protein names	- RNA-binding protein 15 {ECO:0000305} - One-twenty two protein 1 {ECO:0000303\|PubMed:16129689} - RNA-binding motif protein 15 {ECO:0000303\|PubMed:11431691}
Gene names	RBM15
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96T37

11 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Putative RNA-binding protein 15 - Isoform 3 of Putative RNA-binding protein 15 - Isoform 4 of Putative RNA-binding protein 15 - Isoform 2 of RNA-binding protein 15 - Isoform 3 of RNA-binding protein 15 - Isoform 4 of RNA-binding protein 15

Sequence View

        10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL         10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL         10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL         10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL         10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL         10         20         30         40         50         60
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG
        70         80         90        100        110        120
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS
       130        140        150        160        170        180
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ
       190        200        210        220        230        240
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL
       250        260        270        280        290        300
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL
       310        320        330        340        350        360
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE
       370        380        390        400        410        420
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK
       430        440        450        460        470        480
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT
       490        500        510        520        530        540
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP
       550        560        570        580        590        600
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT
       610        620        630        640        650        660
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD
       670        680        690        700        710        720
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK
       730        740        750        760        770        780
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA
       790        800        810        820        830        840
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP
       850        860        870        880        890        900
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA
       910        920        930        940        950        960
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI
       970
GVRYENKKRE NLALTLL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96T37-1-unknown	MRTAGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96T37-1-unknown	MRTAGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87091
Q96T37-1-unknown	MRTAGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87092
Q96T37-45-unknown	MKGKER...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87093
Q96T37-45-unknown	MKGKER...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98842
Q96T37-45-unknown	MKGKER...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98843
Q96T37-179-unknown	SQLSDE...	179	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172394
Q96T37-179-unknown	SQLSDE...	179	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172395
Q96T37-179-unknown	SQLSDE...	179	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172396
Q96T37-179-	SQLSDE...	179		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96T37-179-	SQLSDE...	179		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96T37-179-	SQLSDE...	179		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96T37-271-	SVVGAS...	271		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96T37-271-	SVVGAS...	271		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96T37-271-unknown	SVVGAS...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168230
Q96T37-271-unknown	SVVGAS...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168231
Q96T37-271-unknown	SVVGAS...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168232
Q96T37-604-	SVPAYE...	604		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96T37-604-unknown	SVPAYE...	604	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176899
Q96T37-604-unknown	SVPAYE...	604	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176900
Q96T37-604-unknown	SVPAYE...	604	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176901
Q96T37-744-unknown	KKEDRS...	744	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14881
Q96T37-744-unknown	KKEDRS...	744	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155853
Q96T37-744-unknown	KKEDRS...	744	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156237
Q96T37-744-unknown	KKEDRS...	744	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156238
Q96T37-751-unknown	GSAPST...	751	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165766
Q96T37-751-unknown	GSAPST...	751	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165767
Q96T37-751-unknown	GSAPST...	751	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165768
Q96T37-751-	GSAPST...	751		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96T37-751-	GSAPST...	751		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96T37-751-	GSAPST...	751		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKSPLK	743	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14881
...GKSPLK	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139306
...GKSPLK	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139704
...GKSPLK	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139705
...ALTLL	977	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	743	SPLK.\|.KKED	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)