Q99536: Synaptic vesicle membrane protein VAT-1 homolog

General Information

Protein names	- Synaptic vesicle membrane protein VAT-1 homolog - 1.-.-.-
Gene names	VAT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99536

9 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Synaptic vesicle membrane protein VAT-1 homolog - Isoform 3 of Synaptic vesicle membrane protein VAT-1 homolog

Sequence View

        10         20         30         40         50         60
MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC LVLTGFGGYD
        70         80         90        100        110        120
KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY DRLPPLPVTP GMEGAGVVIA
       130        140        150        160        170        180
VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP SVQTFLIPEA MTFEEAAALL VNYITAYMVL
       190        200        210        220        230        240
FDFGNLQPGH SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY
       250        260        270        280        290        300
HTTDYVDEIK KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA
       310        320        330        340        350        360
LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN QGHIKPHIDS
       370        380        390
VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN         10         20         30         40         50         60
MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC LVLTGFGGYD
        70         80         90        100        110        120
KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY DRLPPLPVTP GMEGAGVVIA
       130        140        150        160        170        180
VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP SVQTFLIPEA MTFEEAAALL VNYITAYMVL
       190        200        210        220        230        240
FDFGNLQPGH SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY
       250        260        270        280        290        300
HTTDYVDEIK KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA
       310        320        330        340        350        360
LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN QGHIKPHIDS
       370        380        390
VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99536-2-unknown	MSDERE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99536-2-Acetylation	SDEREV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99536-7-	VAEAAT...	7			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99536-16-	ASSPPP...	16			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99536-17-	SSPPPK...	17			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99536-17-	SSPPPK...	17			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99536-17-	SSPPPK...	17			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99536-17-	SSPPPK...	17			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99536-135-unknown	MVLNRS...	135		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408553
Q99536-135-unknown	MVLNRS...	135		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466322
Q99536-135-unknown	MVLNRS...	135		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467131
Q99536-135-unknown	MVLNRS...	135		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468146
Q99536-233-	GVTHPI...	233			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99536-233-	GVTHPI...	233			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99536-233-	GVTHPI...	233			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99536-242-unknown	TTDYVD...	242		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18084
Q99536-253-unknown	SPKGVD...	253		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468621

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MWQEEV	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468401
...SASKHE	226	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468146
...PIDYHT	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18084
...KVVTYG	285	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467131
...PEKEN	393	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	241	DYHT.\|.TTDY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)