Q99543: DnaJ homolog subfamily C member 2

General Information

Protein names	- DnaJ homolog subfamily C member 2 - M-phase phosphoprotein 11 - Zuotin-related factor 1 - DnaJ homolog subfamily C member 2, N-terminally processed
Gene names	DNAJC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99543

11 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS
        70         80         90        100        110        120
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP
       130        140        150        160        170        180
DKRKAAGEPI KEGDNDYFTC ITKAYEMLSD PVKRRAFNSV DPTFDNSVPS KSEAKDNFFE
       190        200        210        220        230        240
VFTPVFERNS RWSNKKNVPK LGDMNSSFED VDIFYSFWYN FDSWREFSYL DEEEKEKAEC
       250        260        270        280        290        300
RDERRWIEKQ NRATRAQRKK EEMNRIRTLV DNAYSCDPRI KKFKEEEKAK KEAEKKAKAE
       310        320        330        340        350        360
AKRKEQEAKE KQRQAELEAA RLAKEKEEEE VRQQALLAKK EKDIQKKAIK KERQKLRNSC
       370        380        390        400        410        420
KTWNHFSDNE AERVKMMEEV EKLCDRLELA SLQCLNETLT SCTKEVGKAA LEKQIEEINE
       430        440        450        460        470        480
QIRKEKEEAE ARMRQASKNT EKSTGGGGNG SKNWSEDDLQ LLIKAVNLFP AGTNSRWEVI
       490        500        510        520        530        540
ANYMNIHSSS GVKRTAKDVI GKAKSLQKLD PHQKDDINKK AFDKFKKEHG VVPQADNATP
       550        560        570        580        590        600
SERFEGPYTD FTPWTTEEQK LLEQALKTYP VNTPERWEKI AEAVPGRTKK DCMKRYKELV
       610        620
EMVKAKKAAQ EQVLNASRAK K

Isoforms

- Isoform 2 of DnaJ homolog subfamily C member 2

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99543-1-unknown	MLLLPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73055
Q99543-1-Acetylation	MLLLPS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99543-1-Acetylation	MLLLPS...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q99543-1-Acetylation	MLLLPS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99543-1-Acetylation	MLLLPS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106052
Q99543-2-Acetylation	MLLLPS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99543-1-	MLLLPS...	1			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q99543-1-	MLLLPS...	1			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99543-1-	MLLLPS...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99543-1-	MLLLPS...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99543-1-	MLLLPS...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99543-1-acetylation,unknown	MLLLPS...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99543-2-unknown	LLLPSA...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99543-2-unknown	LLLPSA...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111263
Q99543-135-unknown	NDYFTC...	135		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13137
Q99543-135-unknown	NDYFTC...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144070
Q99543-337-unknown	LAKKEK...	337		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14888
Q99543-337-unknown	LAKKEK...	337		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150653
Q99543-338-unknown	AKKEKD...	338		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14890
Q99543-338-unknown	AKKEKD...	338		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150675
Q99543-527-	KEHGVV...	527			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q99543-527-unknown	KEHGVV...	527		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169879

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IKEGDN	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13137
...IKEGDN	134	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127321
...RQQALL	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14888
...RQQALL	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134051
...QQALLA	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14890
...QQALLA	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134073
...SRAKK	621	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRAKK	621	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68673

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	134	EGDN.\|.NDYF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	336	QALL.\|.LAKK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	337	ALLA.\|.AKKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)