Q99614: Tetratricopeptide repeat protein 1

General Information

Protein names	- Tetratricopeptide repeat protein 1 - TPR repeat protein 1
Gene names	TTC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99614

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE
        70         80         90        100        110        120
ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK
       130        140        150        160        170        180
EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK
       190        200        210        220        230        240
AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN
       250        260        270        280        290
ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99614-1-unknown	MGEKSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q99614-67-	SASFEE...	67		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99614-67-unknown	SASFEE...	67		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q99614-68-	ASFEEE...	68		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99614-68-	ASFEEE...	68		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99614-69-	SFEEEP...	69		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99614-69-	SFEEEP...	69		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99614-69-	SFEEEP...	69		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99614-72-unknown	EEPGAD...	72	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8045
Q99614-169-unknown	DKKEMA...	169	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428613
Q99614-214-	SILEKD...	214		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SASFEE	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8045
	...PNNNR	292	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	71	SFEE.\|.EEPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)