Q99615: DnaJ homolog subfamily C member 7

General Information

Protein names	- DnaJ homolog subfamily C member 7 - Tetratricopeptide repeat protein 2 - TPR repeat protein 2
Gene names	DNAJC7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99615

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK
        70         80         90        100        110        120
NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ
       130        140        150        160        170        180
RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI
       190        200        210        220        230        240
LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA
       250        260        270        280        290        300
PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR
       310        320        330        340        350        360
GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT
       370        380        390        400        410        420
KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV
       430        440        450        460        470        480
QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS
       490
FEASGPGNFF FQFG

Isoforms

- Isoform 2 of DnaJ homolog subfamily C member 7

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99615-2-unknown	MAAAAE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99615-2-Acetylation	AAAAEC...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99615-2-Acetylation	AAAAEC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99615-2-Acetylation	AAAAEC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99615-9-unknown	VVMAAT...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13141
Q99615-9-unknown	VVMAAT...	9			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q99615-9-	VVMAAT...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99615-12-	AATEPE...	12			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q99615-12-	AATEPE...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99615-12-	AATEPE...	12			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99615-12-	AATEPE...	12			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99615-57-unknown	MCPKNA...	57		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73057
Q99615-141-unknown	AVMEYE...	141		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173544
Q99615-141-	AVMEYE...	141			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAECDV	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13141
...FFQFG	494	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FFQFG	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68675

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	8	ECDV.\|.VVMA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)