Q99700: Ataxin-2

General Information

Protein names	- Ataxin-2 - Spinocerebellar ataxia type 2 protein - Trinucleotide repeat-containing gene 13 protein
Gene names	ATXN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99700

6 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ataxin-2 - Isoform 3 of Ataxin-2 - Isoform 4 of Ataxin-2 - Isoform 5 of Ataxin-2

Sequence View

        10         20         30         40         50         60
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP
        70         80         90        100        110        120
GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA
       130        140        150        160        170        180
PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ
       190        200        210        220        230        240
QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP
       250        260        270        280        290        300
GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK
       310        320        330        340        350        360
CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA
       370        380        390        400        410        420
KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS
       430        440        450        460        470        480
SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE
       490        500        510        520        530        540
REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG
       550        560        570        580        590        600
SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS
       610        620        630        640        650        660
AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT
       670        680        690        700        710        720
PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV
       730        740        750        760        770        780
AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN
       790        800        810        820        830        840
KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA
       850        860        870        880        890        900
KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE
       910        920        930        940        950        960
EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ
       970        980        990       1000       1010       1020
PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA
      1030       1040       1050       1060       1070       1080
SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP
      1090       1100       1110       1120       1130       1140
THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL
      1150       1160       1170       1180       1190       1200
HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP
      1210       1220       1230       1240       1250       1260
TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP
      1270       1280       1290       1300       1310
TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL         10         20         30         40         50         60
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP
        70         80         90        100        110        120
GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA
       130        140        150        160        170        180
PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ
       190        200        210        220        230        240
QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP
       250        260        270        280        290        300
GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK
       310        320        330        340        350        360
CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA
       370        380        390        400        410        420
KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS
       430        440        450        460        470        480
SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE
       490        500        510        520        530        540
REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG
       550        560        570        580        590        600
SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS
       610        620        630        640        650        660
AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT
       670        680        690        700        710        720
PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV
       730        740        750        760        770        780
AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN
       790        800        810        820        830        840
KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA
       850        860        870        880        890        900
KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE
       910        920        930        940        950        960
EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ
       970        980        990       1000       1010       1020
PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA
      1030       1040       1050       1060       1070       1080
SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP
      1090       1100       1110       1120       1130       1140
THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL
      1150       1160       1170       1180       1190       1200
HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP
      1210       1220       1230       1240       1250       1260
TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP
      1270       1280       1290       1300       1310
TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL         10         20         30         40         50         60
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP
        70         80         90        100        110        120
GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA
       130        140        150        160        170        180
PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ
       190        200        210        220        230        240
QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP
       250        260        270        280        290        300
GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK
       310        320        330        340        350        360
CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA
       370        380        390        400        410        420
KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS
       430        440        450        460        470        480
SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE
       490        500        510        520        530        540
REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG
       550        560        570        580        590        600
SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS
       610        620        630        640        650        660
AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT
       670        680        690        700        710        720
PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV
       730        740        750        760        770        780
AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN
       790        800        810        820        830        840
KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA
       850        860        870        880        890        900
KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE
       910        920        930        940        950        960
EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ
       970        980        990       1000       1010       1020
PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA
      1030       1040       1050       1060       1070       1080
SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP
      1090       1100       1110       1120       1130       1140
THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL
      1150       1160       1170       1180       1190       1200
HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP
      1210       1220       1230       1240       1250       1260
TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP
      1270       1280       1290       1300       1310
TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL         10         20         30         40         50         60
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP
        70         80         90        100        110        120
GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA
       130        140        150        160        170        180
PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ
       190        200        210        220        230        240
QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP
       250        260        270        280        290        300
GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK
       310        320        330        340        350        360
CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA
       370        380        390        400        410        420
KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS
       430        440        450        460        470        480
SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE
       490        500        510        520        530        540
REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG
       550        560        570        580        590        600
SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS
       610        620        630        640        650        660
AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT
       670        680        690        700        710        720
PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV
       730        740        750        760        770        780
AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN
       790        800        810        820        830        840
KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA
       850        860        870        880        890        900
KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE
       910        920        930        940        950        960
EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ
       970        980        990       1000       1010       1020
PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA
      1030       1040       1050       1060       1070       1080
SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP
      1090       1100       1110       1120       1130       1140
THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL
      1150       1160       1170       1180       1190       1200
HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP
      1210       1220       1230       1240       1250       1260
TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP
      1270       1280       1290       1300       1310
TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99700-1-unknown	MRSAAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99700-1-unknown	MRSAAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68003
Q99700-1-unknown	MRSAAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68005
Q99700-417-unknown	SSLSSY...	417	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2388
Q99700-417-unknown	SSLSSY...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152274
Q99700-417-unknown	SSLSSY...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152275
Q99700-430-unknown	NSEEFL...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13144
Q99700-430-unknown	NSEEFL...	430	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152469
Q99700-430-unknown	NSEEFL...	430	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152470
Q99700-648-unknown	EFVSHN...	648	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14895
Q99700-648-unknown	EFVSHN...	648	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155281
Q99700-648-unknown	EFVSHN...	648	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155282
Q99700-843-unknown	SFIENS...	843	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172508
Q99700-843-unknown	SFIENS...	843	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172509
Q99700-843-	SFIENS...	843		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VSTYDS	416	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2388
...VSTYDS	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135684
...VSTYDS	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135685
...PLERDN	429	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13144
...PLERDN	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135880
...PLERDN	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135881
...ISSGLE	647	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14895
...ISSGLE	647	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138714
...ISSGLE	647	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138715
...NPPHMA	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63623
...NPPHMA	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93721
...HQQQL	1313	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP4_HUMAN	416	TYDS.\|.SSLS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	429	ERDN.\|.NSEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	647	SGLE.\|.EFVS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)