Q99880: Histone H2B type 1-L

General Information

Protein names	- Histone H2B type 1-L - Histone H2B.c - H2B/c
Gene names	HIST1H2BL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99880

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPELAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
        70         80         90        100        110        120
GIMNSFVNDI FERIASEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT

KYTSSK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99880-2-unknown	MPELAK...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q99880-2-unknown	MPELAK...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q99880-2-unknown	MPELAK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99880-2-unknown	MPELAK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99880-2-unknown	MPELAK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99880-2-Acetylation	PELAKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99880-2-Acetylation	PELAKS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q99880-2-	PELAKS...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q99880-2-	PELAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99880-2-	PELAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q99880-2-	PELAKS...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q99880-2-	PELAKS...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q99880-6-unknown	KSAPAP...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14909
Q99880-13-unknown	KGSKKA...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10508
Q99880-22-unknown	AQKKDG...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10509
Q99880-53-unknown	TGISSK...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13153
Q99880-59-unknown	AMGIMN...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10510

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPELAK	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14909
...APAPKK	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10508
...KAVTKA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10509
...QVHPDT	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13153
...GISSKA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10510
...YTSSK	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	ELAK.\|.KSAP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	12	APKK.\|.KGSK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	21	VTKA.\|.AQKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	52	HPDT.\|.TGIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	58	SSKA.\|.AMGI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)