Q9BRT9: DNA replication complex GINS protein SLD5

General Information

Protein names	- DNA replication complex GINS protein SLD5 - GINS complex subunit 4 - DNA replication complex GINS protein SLD5, N-terminally processed
Gene names	GINS4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BRT9

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTEEVDFLGQ DSDGGSEEVV LTPAELIERL EQAWMNEKFA PELLESKPEI VECVMEQLEH
        70         80         90        100        110        120
MEENLRRAKR EDLKVSIHQM EMERIRYVLS SYLRCRLMKI EKFFPHVLEK EKTRPEGEPS
       130        140        150        160        170        180
SLSPEELAFA REFMANTESY LKNVALKHMP PNLQKVDLFR AVPKPDLDSY VFLRVRERQE
       190        200        210        220
NILVEPDTDE QRDYVIDLEK GSQHLIRYKT IAPLVASGAV QLI

Isoforms

- Isoform 2 of DNA replication complex GINS protein SLD5

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BRT9-1-Acetylation	MTEEVD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BRT9-1-Acetylation	MTEEVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99139
Q9BRT9-1-unknown	MTEEVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89937
Q9BRT9-2-Acetylation	TEEVDF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BRT9-2-Acetylation	TEEVDF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110459
Q9BRT9-7-	FLGQDS...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BRT9-7-	FLGQDS...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9BRT9-7-	FLGQDS...	7			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q9BRT9-7-unknown	FLGQDS...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171181
Q9BRT9-14-	GGSEEV...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BRT9-14-unknown	GGSEEV...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172389

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SGAVQL	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13189
...AVQLI	223		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AVQLI	223		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AVQLI	223	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AVQLI	223		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AVQLI	223		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	221	AVQL.\|.LI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)