Q9BVP2: Guanine nucleotide-binding protein-like 3

General Information

Protein names	- Guanine nucleotide-binding protein-like 3 - E2-induced gene 3 protein - Novel nucleolar protein 47 - NNP47 - Nucleolar GTP-binding protein 3 - Nucleostemin
Gene names	GNL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BVP2

11 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV PNSAPFKEAL
        70         80         90        100        110        120
LREAELRKQR LEELKQQQKL DRQKELEKKR KLETNPDIKP SNVEPMEKEF GLCKTENKAK
       130        140        150        160        170        180
SGKQNSKKLY CQELKKVIEA SDVVLEVLDA RDPLGCRCPQ VEEAIVQSGQ KKLVLILNKS
       190        200        210        220        230        240
DLVPKENLES WLNYLKKELP TVVFRASTKP KDKGKITKRV KAKKNAAPFR SEVCFGKEGL
       250        260        270        280        290        300
WKLLGGFQET CSKAIRVGVI GFPNVGKSSI INSLKQEQMC NVGVSMGLTR SMQVVPLDKQ
       310        320        330        340        350        360
ITIIDSPSFI VSPLNSSSAL ALRSPASIEV VKPMEAASAI LSQADARQVV LKYTVPGYRN
       370        380        390        400        410        420
SLEFFTVLAQ RRGMHQKGGI PNVEGAAKLL WSEWTGASLA YYCHPPTSWT PPPYFNESIV
       430        440        450        460        470        480
VDMKSGFNLE ELEKNNAQSI RAIKGPHLAN SILFQSSGLT NGIIEEKDIH EELPKRKERK
       490        500        510        520        530        540
QEEREDDKDS DQETVDEEVD ENSSGMFAAE ETGEALSEET TAGEQSTRSF ILDKIIEEDD

AYDFSTDYV

Isoforms

- Isoform 2 of Guanine nucleotide-binding protein-like 3

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BVP2-1-unknown	MKRPKL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BVP2-13-unknown	MTCHKR...	13	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76164
Q9BVP2-107-unknown	EKEFGL...	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14965
Q9BVP2-107-unknown	EKEFGL...	107	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142133
Q9BVP2-142-unknown	DVVLEV...	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13220
Q9BVP2-142-unknown	DVVLEV...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143908
Q9BVP2-291-	SMQVVP...	291		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9BVP2-291-unknown	SMQVVP...	291		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9BVP2-291-unknown	SMQVVP...	291	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159683
Q9BVP2-308-unknown	SFIVSP...	308	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171500
Q9BVP2-308-	SFIVSP...	308		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BVP2-315-unknown	NSSSAL...	315	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14967
Q9BVP2-315-unknown	NSSSAL...	315	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149950
Q9BVP2-503-unknown	SSGMFA...	503	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13222
Q9BVP2-503-unknown	SSGMFA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153317
Q9BVP2-540-unknown	DAYDFS...	540	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13224
Q9BVP2-540-unknown	DAYDFS...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153729

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVEPME	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14965
...NVEPME	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125318
...VIEASD	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13220
...VIEASD	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127152
...IVSPLN	314	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14967
...IVSPLN	314	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133342
...EVDENS	502	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13222
...EVDENS	502	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136741
...IIEEDD	539	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13224
...IIEEDD	539	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137152
...STDYV	549	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...STDYV	549	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71782

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	106	EPME.\|.EKEF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	141	EASD.\|.DVVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	314	SPLN.\|.NSSS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	502	DENS.\|.SSGM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	539	EEDD.\|.DAYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)