Q9H2G2: STE20-like serine/threonine-protein kinase

General Information

Protein names	- STE20-like serine/threonine-protein kinase - STE20-like kinase - hSLK - 2.7.11.1 - CTCL tumor antigen se20-9 - STE20-related serine/threonine-protein kinase - STE20-related kinase - Serine/threonine-protein kinase 2
Gene names	SLK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H2G2

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK AQNKETSVLA
        70         80         90        100        110        120
AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM
       130        140        150        160        170        180
LELERPLTES QIQVVCKQTL DALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN
       190        200        210        220        230        240
TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP
       250        260        270        280        290        300
MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI
       310        320        330        340        350        360
RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL
       370        380        390        400        410        420
ESVSEKTERS NSEDKLNSKI LNEKPTTDEP EKAVEDINEH ITDAQLEAMT ELHDRTAVIK
       430        440        450        460        470        480
ENEREKRPKL ENLPDTEDQE TVDINSVSEG KENNIMITLE TNIEHNLKSE EEKDQEKQQM
       490        500        510        520        530        540
FENKLIKSEE IKDTILQTVD LVSQETGEKE ANIQAVDSEV GLTKEDTQEK LGEDDKTQKD
       550        560        570        580        590        600
VISNTSDVIG TCEAADVAQK VDEDSAEDTQ SNDGKEVVEV GQKLINKPMV GPEAGGTKEV
       610        620        630        640        650        660
PIKEIVEMNE IEEGKNKEQA INSSENIMDI NEEPGTTEGE EITESSSTEE MEVRSVVADT
       670        680        690        700        710        720
DQKALGSEVQ DASKVTTQID KEKKEIPVSI KKEPEVTVVS QPTEPQPVLI PSININSDSG
       730        740        750        760        770        780
ENKEEIGSLS KTETILPPES ENPKENDNDS GTGSTADTSS IDLNLSISSF LSKTKDSGSI
       790        800        810        820        830        840
SLQETRRQKK TLKKTRKFIV DGVEVSVTTS KIVTDSDSKT EELRFLRRQE LRELRFLQKE
       850        860        870        880        890        900
EQRAQQQLNS KLQQQREQIF RRFEQEMMSK KRQYDQEIEN LEKQQKQTIE RLEQEHTNRL
       910        920        930        940        950        960
RDEAKRIKGE QEKELSKFQN MLKNRKKEVI NEVEKAPKEL RKELMKRRKE ELAQSQHAQE
       970        980        990       1000       1010       1020
QEFVQKQQQE LDGSLKKIIQ QQKAELANIE RECLNNKQQL MRAREAAIWE LEERHLQEKH
      1030       1040       1050       1060       1070       1080
QLLKQQLKDQ YFMQRHQLLK RHEKETEQMQ RYNQRLIEEL KNRQTQERAR LPKIQRSEAK
      1090       1100       1110       1120       1130       1140
TRMAMFKKSL RINSTATPDQ DRDKIKQFAA QEEKRQKNER MAQHQKHENQ MRDLQLQCEA
      1150       1160       1170       1180       1190       1200
NVRELHQLQN EKCHLLVEHE TQKLKELDEE HSQELKEWRE KLRPRKKTLE EEFARKLQEQ
      1210       1220       1230
EVFFKMTGES ECLNPSTQSR ISKFYPIPSL HSTGS

Isoforms

- Isoform 2 of STE20-like serine/threonine-protein kinase

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H2G2-1-unknown	MSFFNF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H2G2-1-unknown	MSFFNF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89950
Q9H2G2-2-acetylation	SFFNFR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H2G2-2-acetylation	SFFNFR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H2G2-2-acetylation	SFFNFR...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163009
Q9H2G2-85-unknown	SCDHPN...	85		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8083
Q9H2G2-85-unknown	SCDHPN...	85		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141583
Q9H2G2-383-unknown	EKPTTD...	383		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8085
Q9H2G2-383-unknown	EKPTTD...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151703
Q9H2G2-404-	AQLEAM...	404			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H2G2-404-unknown	AQLEAM...	404		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171713
Q9H2G2-816-unknown	SDSKTE...	816		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13291
Q9H2G2-816-unknown	SDSKTE...	816		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156559

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IDILAS	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8083
...IDILAS	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124760
...SKILNE	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8085
...SKILNE	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135107
...KIVTDS	815	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13291
...KIVTDS	815	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140043
...HSTGS	1235	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSTGS	1235	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85568

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	84	ILAS.\|.SCDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	382	ILNE.\|.EKPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	815	VTDS.\|.SDSK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)