Q9H6R7: WD repeat and coiled-coil-containing protein {ECO:0000305}

General Information

Protein names	- WD repeat and coiled-coil-containing protein {ECO:0000305}
Gene names	C2orf44
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6R7

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of WD repeat-containing protein C2orf44 - Isoform 3 of WD repeat-containing protein C2orf44 - Isoform 2 of WD repeat and coiled-coil-containing protein - Isoform 3 of WD repeat and coiled-coil-containing protein

Sequence View

        10         20         30         40         50         60
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
        70         80         90        100        110        120
CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
       130        140        150        160        170        180
WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
       190        200        210        220        230        240
SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
       250        260        270        280        290        300
PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
       310        320        330        340        350        360
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
       370        380        390        400        410        420
CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
       430        440        450        460        470        480
QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
       490        500        510        520        530        540
TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
       550        560        570        580        590        600
RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
       610        620        630        640        650        660
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
       670        680        690        700        710        720
PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM

A         10         20         30         40         50         60
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
        70         80         90        100        110        120
CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
       130        140        150        160        170        180
WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
       190        200        210        220        230        240
SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
       250        260        270        280        290        300
PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
       310        320        330        340        350        360
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
       370        380        390        400        410        420
CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
       430        440        450        460        470        480
QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
       490        500        510        520        530        540
TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
       550        560        570        580        590        600
RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
       610        620        630        640        650        660
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
       670        680        690        700        710        720
PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM

A         10         20         30         40         50         60
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
        70         80         90        100        110        120
CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
       130        140        150        160        170        180
WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
       190        200        210        220        230        240
SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
       250        260        270        280        290        300
PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
       310        320        330        340        350        360
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
       370        380        390        400        410        420
CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
       430        440        450        460        470        480
QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
       490        500        510        520        530        540
TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
       550        560        570        580        590        600
RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
       610        620        630        640        650        660
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
       670        680        690        700        710        720
PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM

A         10         20         30         40         50         60
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
        70         80         90        100        110        120
CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
       130        140        150        160        170        180
WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
       190        200        210        220        230        240
SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
       250        260        270        280        290        300
PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
       310        320        330        340        350        360
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
       370        380        390        400        410        420
CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
       430        440        450        460        470        480
QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
       490        500        510        520        530        540
TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
       550        560        570        580        590        600
RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
       610        620        630        640        650        660
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
       670        680        690        700        710        720
PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM

A

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H6R7-1-unknown	MELGKG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69402
Q9H6R7-1-Acetylation	MELGKG...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H6R7-1-Acetylation	MELGKG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H6R7-1-Acetylation	MELGKG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H6R7-1-Acetylation	MELGKG...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107074
Q9H6R7-504-unknown	SSICDG...	504		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15000
Q9H6R7-504-unknown	SSICDG...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136645
Q9H6R7-504-unknown	SSICDG...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153458
Q9H6R7-509-	GSIALD...	509			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H6R7-509-	GSIALD...	509			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H6R7-509-	GSIALD...	509			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H6R7-509-	GSIALD...	509			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H6R7-509-	GSIALD...	509			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H6R7-509-unknown	GSIALD...	509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168238
Q9H6R7-509-unknown	GSIALD...	509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168239

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IQSPLS	503	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15000
...IQSPLS	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136881
...VDGMA	721	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VDGMA	721	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65021

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	503	SPLS.\|.SSIC	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)