Q9HCK8: Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071}
Protein names | - Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071} - CHD-8 {ECO:0000255|HAMAP-Rule:MF_03071} - 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03071} - ATP-dependent helicase CHD8 {ECO:0000255|HAMAP-Rule:MF_03071} - Helicase with SNF2 domain 1 |
---|---|
Gene names | CHD8 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9HCK8 |
10
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
70 80 90 100 110 120
SSASELVPPP EETAPTELSK ESTAPAPESI TLHDYTTQPA SQEQPAQPVL QTSTPTSGLL
130 140 150 160 170 180
QVSKSQEILS QGNPFMGVSA TAVSSSSAGG QPPQSAPKIV ILKAPPSSSV TGAHVAQIQA
190 200 210 220 230 240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLAAKVPG NQAAVQRIVQ
250 260 270 280 290 300
PSRPVKQLVL QPVKGSAPAG NPGATGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
310 320 330 340 350 360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
370 380 390 400 410 420
QPQPQQPPST QPVTLSSVQQ AQIMGPGQSP GQRLSVPVKV VLQPQAGSSQ GASSGLSVVK
430 440 450 460 470 480
VLSASEVAAL SSPASSAPHS GGKTGMEENR RLEHQKKQEK ANRIVAEAIA RARARGEQNI
490 500 510 520 530 540
PRVLNEDELP SVRPEEEGEK KRRKKSAGER LKEEKPKKSK TSGASKTKGK SKLNTITPVV
550 560 570 580 590 600
GKKRKRNTSS DNSDVEVMPA QSPREDEESS IQKRRSNRQV KRKKYTEDLD IKITDDEEEE
610 620 630 640 650 660
EVDVTGPIKP EPILPEPVQE PDGETLPSMQ FFVENPSEED AAIVDKVLSM RIVKKELPSG
670 680 690 700 710 720
QYTEAEEFFV KYKNYSYLHC EWATISQLEK DKRIHQKLKR FKTKMAQMRH FFHEDEEPFN
730 740 750 760 770 780
PDYVEVDRIL DESHSIDKDN GEPVIYYLVK WCSLPYEDST WELKEDVDEG KIREFKRIQS
790 800 810 820 830 840
RHPELKRVNR PQASAWKKLE LSHEYKNRNQ LREYQLEGVN WLLFNWYNRQ NCILADEMGL
850 860 870 880 890 900
GKTIQSIAFL QEVYNVGIHG PFLVIAPLST ITNWEREFNT WTEMNTIVYH GSLASRQMIQ
910 920 930 940 950 960
QYEMYCKDSR GRLIPGAYKF DALITTFEMI LSDCPELREI EWRCVIIDEA HRLKNRNCKL
970 980 990 1000 1010 1020
LDSLKHMDLE HKVLLTGTPL QNTVEELFSL LHFLEPSQFP SESEFLKDFG DLKTEEQVQK
1030 1040 1050 1060 1070 1080
LQAILKPMML RRLKEDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS FLSKGAGHTN
1090 1100 1110 1120 1130 1140
MPNLLNTMME LRKCCNHPYL INGAEEKILT EFREACHIIP HDFHLQAMVR SAGKLVLIDK
1150 1160 1170 1180 1190 1200
LLPKLKAGGH KVLIFSQMVR CLDILEDYLI QRRYLYERID GRVRGNLRQA AIDRFSKPDS
1210 1220 1230 1240 1250 1260
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK AVKVYRLITR
1270 1280 1290 1300 1310 1320
NSYEREMFDK ASLKLGLDKA VLQSMSGRDG NITGIQQFSK KEIEDLLRKG AYAAIMEEDD
1330 1340 1350 1360 1370 1380
EGSKFCEEDI DQILLRRTTT ITIESEGKGS TFAKASFVAS ENRTDISLDD PNFWQKWAKK
1390 1400 1410 1420 1430 1440
ADLDMDLLNS KNNLVIDTPR VRKQTRHFST LKDDDLVEFS DLESEDDERP RSRRHDRHHA
1450 1460 1470 1480 1490 1500
YGRTDCFRVE KHLLVYGWGR WRDILSHGRF KRRMTERDVE TICRAILVYC LLHYRGDENI
1510 1520 1530 1540 1550 1560
KGFIWDLISP AENGKTKELQ NHSGLSIPVP RGRKGKKVKS QSTFDIHKAD WIRKYNPDTL
1570 1580 1590 1600 1610 1620
FQDESYKKHL KHQCNKVLLR VRMLYYLRQE VIGDQAEKVL GGAIASEIDI WFPVVDQLEV
1630 1640 1650 1660 1670 1680
PTTWWDSEAD KSLLIGVFKH GYEKYNTMRA DPALCFLEKA GRPDDKAIAA EHRVLDNFSD
1690 1700 1710 1720 1730 1740
IVEGVDFDKD CEDPEYKPLQ GPPKDQDDEG DPLMMMDEEI SVIDGDEAQV TQQPGHLFWP
1750 1760 1770 1780 1790 1800
PGSALTARLR RLVTAYQRSY KREQMKIEAA ERGDRRRRRC EAAFKLKEIA RREKQQRWTR
1810 1820 1830 1840 1850 1860
REQTDFYRVV STFGVEYDPD TMQFHWDRFR TFARLDKKTD ESLTKYFHGF VAMCRQVCRL
1870 1880 1890 1900 1910 1920
PPAAGDEPPD PNLFIEPITE ERASRTLYRI ELLRRLREQV LCHPLLEDRL ALCQPPGPEL
1930 1940 1950 1960 1970 1980
PKWWEPVRHD GELLRGAARH GVSQTDCNIM QDPDFSFLAA RMNYMQNHQA GAPAPSLSRC
1990 2000 2010 2020 2030 2040
STPLLHQQYT SRTASPLPLR PDAPVEKSPE ETATQVPSLE SLTLKLEHEV VARSRPTPQD
2050 2060 2070 2080 2090 2100
YEMRVSPSDT TPLVSRSVPP VKLEDEDDSD SELDLSKLSP SSSSSSSSSS SSSSTDESED
2110 2120 2130 2140 2150 2160
EKEEKLTDQS RSKLYDEESL LSLTMSQDGF PNEDGEQMTP ELLLLQERQR ASEWPKDRVL
2170 2180 2190 2200 2210 2220
INRIDLVCQA VLSGKWPSSR RSQEMVTGGI LGPGNHLLDS PSLTPGEYGD SPVPTPRSSS
2230 2240 2250 2260 2270 2280
AASMAEEEAS AVSTAAAQFT KLRRGMDEKE FTVQIKDEEG LKLTFQKHKL MANGVMGDGH
2290 2300 2310 2320 2330 2340
PLFHKKKGNR KKLVELEVEC MEEPNHLDVD LETRIPVINK VDGTLLVGED APRRAELEMW
2350 2360 2370 2380 2390 2400
LQGHPEFAVD PRFLAYMEDR RKQKWQRCKK NNKAELNCLG MEPVQTANSR NGKKGHHTET
2410 2420 2430 2440 2450 2460
VFNRVLPGPI APESSKKRAR RMRPDLSKMM ALMQGGSTGS LSLHNTFQHS SSGLQSVSSL
2470 2480 2490 2500 2510 2520
GHSSATSASL PFMPFVMGGA PSSPHVDSST MLHHHHHHPH PHHHHHHHPG LRAPGYPSSP
2530 2540 2550 2560 2570 2580
VTTASGTTLR LPPLQPEEDD DEDEEDDDDL SQGYDSSERD FSLIDDPMMP ANSDSSEDAD
D
Isoforms
- Isoform 2 of Chromodomain-helicase-DNA-binding protein 8Sequence View
10 20 30 40 50 60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
70 80 90 100 110 120
SSASELVPPP EETAPTELSK ESTAPAPESI TLHDYTTQPA SQEQPAQPVL QTSTPTSGLL
130 140 150 160 170 180
QVSKSQEILS QGNPFMGVSA TAVSSSSAGG QPPQSAPKIV ILKAPPSSSV TGAHVAQIQA
190 200 210 220 230 240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLAAKVPG NQAAVQRIVQ
250 260 270 280 290 300
PSRPVKQLVL QPVKGSAPAG NPGATGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
310 320 330 340 350 360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
370 380 390 400 410 420
QPQPQQPPST QPVTLSSVQQ AQIMGPGQSP GQRLSVPVKV VLQPQAGSSQ GASSGLSVVK
430 440 450 460 470 480
VLSASEVAAL SSPASSAPHS GGKTGMEENR RLEHQKKQEK ANRIVAEAIA RARARGEQNI
490 500 510 520 530 540
PRVLNEDELP SVRPEEEGEK KRRKKSAGER LKEEKPKKSK TSGASKTKGK SKLNTITPVV
550 560 570 580 590 600
GKKRKRNTSS DNSDVEVMPA QSPREDEESS IQKRRSNRQV KRKKYTEDLD IKITDDEEEE
610 620 630 640 650 660
EVDVTGPIKP EPILPEPVQE PDGETLPSMQ FFVENPSEED AAIVDKVLSM RIVKKELPSG
670 680 690 700 710 720
QYTEAEEFFV KYKNYSYLHC EWATISQLEK DKRIHQKLKR FKTKMAQMRH FFHEDEEPFN
730 740 750 760 770 780
PDYVEVDRIL DESHSIDKDN GEPVIYYLVK WCSLPYEDST WELKEDVDEG KIREFKRIQS
790 800 810 820 830 840
RHPELKRVNR PQASAWKKLE LSHEYKNRNQ LREYQLEGVN WLLFNWYNRQ NCILADEMGL
850 860 870 880 890 900
GKTIQSIAFL QEVYNVGIHG PFLVIAPLST ITNWEREFNT WTEMNTIVYH GSLASRQMIQ
910 920 930 940 950 960
QYEMYCKDSR GRLIPGAYKF DALITTFEMI LSDCPELREI EWRCVIIDEA HRLKNRNCKL
970 980 990 1000 1010 1020
LDSLKHMDLE HKVLLTGTPL QNTVEELFSL LHFLEPSQFP SESEFLKDFG DLKTEEQVQK
1030 1040 1050 1060 1070 1080
LQAILKPMML RRLKEDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS FLSKGAGHTN
1090 1100 1110 1120 1130 1140
MPNLLNTMME LRKCCNHPYL INGAEEKILT EFREACHIIP HDFHLQAMVR SAGKLVLIDK
1150 1160 1170 1180 1190 1200
LLPKLKAGGH KVLIFSQMVR CLDILEDYLI QRRYLYERID GRVRGNLRQA AIDRFSKPDS
1210 1220 1230 1240 1250 1260
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK AVKVYRLITR
1270 1280 1290 1300 1310 1320
NSYEREMFDK ASLKLGLDKA VLQSMSGRDG NITGIQQFSK KEIEDLLRKG AYAAIMEEDD
1330 1340 1350 1360 1370 1380
EGSKFCEEDI DQILLRRTTT ITIESEGKGS TFAKASFVAS ENRTDISLDD PNFWQKWAKK
1390 1400 1410 1420 1430 1440
ADLDMDLLNS KNNLVIDTPR VRKQTRHFST LKDDDLVEFS DLESEDDERP RSRRHDRHHA
1450 1460 1470 1480 1490 1500
YGRTDCFRVE KHLLVYGWGR WRDILSHGRF KRRMTERDVE TICRAILVYC LLHYRGDENI
1510 1520 1530 1540 1550 1560
KGFIWDLISP AENGKTKELQ NHSGLSIPVP RGRKGKKVKS QSTFDIHKAD WIRKYNPDTL
1570 1580 1590 1600 1610 1620
FQDESYKKHL KHQCNKVLLR VRMLYYLRQE VIGDQAEKVL GGAIASEIDI WFPVVDQLEV
1630 1640 1650 1660 1670 1680
PTTWWDSEAD KSLLIGVFKH GYEKYNTMRA DPALCFLEKA GRPDDKAIAA EHRVLDNFSD
1690 1700 1710 1720 1730 1740
IVEGVDFDKD CEDPEYKPLQ GPPKDQDDEG DPLMMMDEEI SVIDGDEAQV TQQPGHLFWP
1750 1760 1770 1780 1790 1800
PGSALTARLR RLVTAYQRSY KREQMKIEAA ERGDRRRRRC EAAFKLKEIA RREKQQRWTR
1810 1820 1830 1840 1850 1860
REQTDFYRVV STFGVEYDPD TMQFHWDRFR TFARLDKKTD ESLTKYFHGF VAMCRQVCRL
1870 1880 1890 1900 1910 1920
PPAAGDEPPD PNLFIEPITE ERASRTLYRI ELLRRLREQV LCHPLLEDRL ALCQPPGPEL
1930 1940 1950 1960 1970 1980
PKWWEPVRHD GELLRGAARH GVSQTDCNIM QDPDFSFLAA RMNYMQNHQA GAPAPSLSRC
1990 2000 2010 2020 2030 2040
STPLLHQQYT SRTASPLPLR PDAPVEKSPE ETATQVPSLE SLTLKLEHEV VARSRPTPQD
2050 2060 2070 2080 2090 2100
YEMRVSPSDT TPLVSRSVPP VKLEDEDDSD SELDLSKLSP SSSSSSSSSS SSSSTDESED
2110 2120 2130 2140 2150 2160
EKEEKLTDQS RSKLYDEESL LSLTMSQDGF PNEDGEQMTP ELLLLQERQR ASEWPKDRVL
2170 2180 2190 2200 2210 2220
INRIDLVCQA VLSGKWPSSR RSQEMVTGGI LGPGNHLLDS PSLTPGEYGD SPVPTPRSSS
2230 2240 2250 2260 2270 2280
AASMAEEEAS AVSTAAAQFT KLRRGMDEKE FTVQIKDEEG LKLTFQKHKL MANGVMGDGH
2290 2300 2310 2320 2330 2340
PLFHKKKGNR KKLVELEVEC MEEPNHLDVD LETRIPVINK VDGTLLVGED APRRAELEMW
2350 2360 2370 2380 2390 2400
LQGHPEFAVD PRFLAYMEDR RKQKWQRCKK NNKAELNCLG MEPVQTANSR NGKKGHHTET
2410 2420 2430 2440 2450 2460
VFNRVLPGPI APESSKKRAR RMRPDLSKMM ALMQGGSTGS LSLHNTFQHS SSGLQSVSSL
2470 2480 2490 2500 2510 2520
GHSSATSASL PFMPFVMGGA PSSPHVDSST MLHHHHHHPH PHHHHHHHPG LRAPGYPSSP
2530 2540 2550 2560 2570 2580
VTTASGTTLR LPPLQPEEDD DEDEEDDDDL SQGYDSSERD FSLIDDPMMP ANSDSSEDAD
D
Protein Neighborhood
Domains & Features
10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9HCK8-1-unknown | MADPIM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9HCK8-377-unknown | SVQQAQ... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172493 | |||
Q9HCK8-377- | SVQQAQ... | 377 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9HCK8-1279-unknown | KAVLQS... | 1279 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13361 | |||
Q9HCK8-1279-unknown | KAVLQS... | 1279 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157153 | |||
Q9HCK8-1689-unknown | KDCEDP... | 1689 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13363 | |||
Q9HCK8-1689-unknown | KDCEDP... | 1689 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt158057 | |||
Q9HCK8-2202-unknown | SLTPGE... | 2202 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167890 | |||
Q9HCK8-2202- | SLTPGE... | 2202 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9HCK8-2202- | SLTPGE... | 2202 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9HCK8-2202- | SLTPGE... | 2202 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9HCK8-2202- | SLTPGE... | 2202 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9HCK8-2218-unknown | SSSAAS... | 2218 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170915 | |||
Q9HCK8-2218- | SSSAAS... | 2218 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9HCK8-2218- | SSSAAS... | 2218 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9HCK8-2300-unknown | CMEEPN... | 2300 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13365 | |||
Q9HCK8-2300-unknown | CMEEPN... | 2300 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt158800 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KLGLDK | 1278 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13361 | |||
...KLGLDK | 1278 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140654 | |||
...GVDFDK | 1688 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13363 | |||
...GVDFDK | 1688 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141552 | |||
...ELEVEC | 2299 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13365 | |||
...ELEVEC | 2299 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt142304 | |||
...EDADD | 2581 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EDADD | 2581 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt66139 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 1278 | GLDK.|.KAVL | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
GRAB_HUMAN | 1688 | DFDK.|.KDCE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
GRAB_HUMAN | 2299 | EVEC.|.CMEE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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