Q9HCK8: Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071}

General Information

Protein names	- Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255\|HAMAP-Rule:MF_03071} - CHD-8 {ECO:0000255\|HAMAP-Rule:MF_03071} - 3.6.4.12 {ECO:0000255\|HAMAP-Rule:MF_03071} - ATP-dependent helicase CHD8 {ECO:0000255\|HAMAP-Rule:MF_03071} - Helicase with SNF2 domain 1
Gene names	CHD8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HCK8

10 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
        70         80         90        100        110        120
SSASELVPPP EETAPTELSK ESTAPAPESI TLHDYTTQPA SQEQPAQPVL QTSTPTSGLL
       130        140        150        160        170        180
QVSKSQEILS QGNPFMGVSA TAVSSSSAGG QPPQSAPKIV ILKAPPSSSV TGAHVAQIQA
       190        200        210        220        230        240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLAAKVPG NQAAVQRIVQ
       250        260        270        280        290        300
PSRPVKQLVL QPVKGSAPAG NPGATGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
       310        320        330        340        350        360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
       370        380        390        400        410        420
QPQPQQPPST QPVTLSSVQQ AQIMGPGQSP GQRLSVPVKV VLQPQAGSSQ GASSGLSVVK
       430        440        450        460        470        480
VLSASEVAAL SSPASSAPHS GGKTGMEENR RLEHQKKQEK ANRIVAEAIA RARARGEQNI
       490        500        510        520        530        540
PRVLNEDELP SVRPEEEGEK KRRKKSAGER LKEEKPKKSK TSGASKTKGK SKLNTITPVV
       550        560        570        580        590        600
GKKRKRNTSS DNSDVEVMPA QSPREDEESS IQKRRSNRQV KRKKYTEDLD IKITDDEEEE
       610        620        630        640        650        660
EVDVTGPIKP EPILPEPVQE PDGETLPSMQ FFVENPSEED AAIVDKVLSM RIVKKELPSG
       670        680        690        700        710        720
QYTEAEEFFV KYKNYSYLHC EWATISQLEK DKRIHQKLKR FKTKMAQMRH FFHEDEEPFN
       730        740        750        760        770        780
PDYVEVDRIL DESHSIDKDN GEPVIYYLVK WCSLPYEDST WELKEDVDEG KIREFKRIQS
       790        800        810        820        830        840
RHPELKRVNR PQASAWKKLE LSHEYKNRNQ LREYQLEGVN WLLFNWYNRQ NCILADEMGL
       850        860        870        880        890        900
GKTIQSIAFL QEVYNVGIHG PFLVIAPLST ITNWEREFNT WTEMNTIVYH GSLASRQMIQ
       910        920        930        940        950        960
QYEMYCKDSR GRLIPGAYKF DALITTFEMI LSDCPELREI EWRCVIIDEA HRLKNRNCKL
       970        980        990       1000       1010       1020
LDSLKHMDLE HKVLLTGTPL QNTVEELFSL LHFLEPSQFP SESEFLKDFG DLKTEEQVQK
      1030       1040       1050       1060       1070       1080
LQAILKPMML RRLKEDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS FLSKGAGHTN
      1090       1100       1110       1120       1130       1140
MPNLLNTMME LRKCCNHPYL INGAEEKILT EFREACHIIP HDFHLQAMVR SAGKLVLIDK
      1150       1160       1170       1180       1190       1200
LLPKLKAGGH KVLIFSQMVR CLDILEDYLI QRRYLYERID GRVRGNLRQA AIDRFSKPDS
      1210       1220       1230       1240       1250       1260
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK AVKVYRLITR
      1270       1280       1290       1300       1310       1320
NSYEREMFDK ASLKLGLDKA VLQSMSGRDG NITGIQQFSK KEIEDLLRKG AYAAIMEEDD
      1330       1340       1350       1360       1370       1380
EGSKFCEEDI DQILLRRTTT ITIESEGKGS TFAKASFVAS ENRTDISLDD PNFWQKWAKK
      1390       1400       1410       1420       1430       1440
ADLDMDLLNS KNNLVIDTPR VRKQTRHFST LKDDDLVEFS DLESEDDERP RSRRHDRHHA
      1450       1460       1470       1480       1490       1500
YGRTDCFRVE KHLLVYGWGR WRDILSHGRF KRRMTERDVE TICRAILVYC LLHYRGDENI
      1510       1520       1530       1540       1550       1560
KGFIWDLISP AENGKTKELQ NHSGLSIPVP RGRKGKKVKS QSTFDIHKAD WIRKYNPDTL
      1570       1580       1590       1600       1610       1620
FQDESYKKHL KHQCNKVLLR VRMLYYLRQE VIGDQAEKVL GGAIASEIDI WFPVVDQLEV
      1630       1640       1650       1660       1670       1680
PTTWWDSEAD KSLLIGVFKH GYEKYNTMRA DPALCFLEKA GRPDDKAIAA EHRVLDNFSD
      1690       1700       1710       1720       1730       1740
IVEGVDFDKD CEDPEYKPLQ GPPKDQDDEG DPLMMMDEEI SVIDGDEAQV TQQPGHLFWP
      1750       1760       1770       1780       1790       1800
PGSALTARLR RLVTAYQRSY KREQMKIEAA ERGDRRRRRC EAAFKLKEIA RREKQQRWTR
      1810       1820       1830       1840       1850       1860
REQTDFYRVV STFGVEYDPD TMQFHWDRFR TFARLDKKTD ESLTKYFHGF VAMCRQVCRL
      1870       1880       1890       1900       1910       1920
PPAAGDEPPD PNLFIEPITE ERASRTLYRI ELLRRLREQV LCHPLLEDRL ALCQPPGPEL
      1930       1940       1950       1960       1970       1980
PKWWEPVRHD GELLRGAARH GVSQTDCNIM QDPDFSFLAA RMNYMQNHQA GAPAPSLSRC
      1990       2000       2010       2020       2030       2040
STPLLHQQYT SRTASPLPLR PDAPVEKSPE ETATQVPSLE SLTLKLEHEV VARSRPTPQD
      2050       2060       2070       2080       2090       2100
YEMRVSPSDT TPLVSRSVPP VKLEDEDDSD SELDLSKLSP SSSSSSSSSS SSSSTDESED
      2110       2120       2130       2140       2150       2160
EKEEKLTDQS RSKLYDEESL LSLTMSQDGF PNEDGEQMTP ELLLLQERQR ASEWPKDRVL
      2170       2180       2190       2200       2210       2220
INRIDLVCQA VLSGKWPSSR RSQEMVTGGI LGPGNHLLDS PSLTPGEYGD SPVPTPRSSS
      2230       2240       2250       2260       2270       2280
AASMAEEEAS AVSTAAAQFT KLRRGMDEKE FTVQIKDEEG LKLTFQKHKL MANGVMGDGH
      2290       2300       2310       2320       2330       2340
PLFHKKKGNR KKLVELEVEC MEEPNHLDVD LETRIPVINK VDGTLLVGED APRRAELEMW
      2350       2360       2370       2380       2390       2400
LQGHPEFAVD PRFLAYMEDR RKQKWQRCKK NNKAELNCLG MEPVQTANSR NGKKGHHTET
      2410       2420       2430       2440       2450       2460
VFNRVLPGPI APESSKKRAR RMRPDLSKMM ALMQGGSTGS LSLHNTFQHS SSGLQSVSSL
      2470       2480       2490       2500       2510       2520
GHSSATSASL PFMPFVMGGA PSSPHVDSST MLHHHHHHPH PHHHHHHHPG LRAPGYPSSP
      2530       2540       2550       2560       2570       2580
VTTASGTTLR LPPLQPEEDD DEDEEDDDDL SQGYDSSERD FSLIDDPMMP ANSDSSEDAD

D

Isoforms

- Isoform 2 of Chromodomain-helicase-DNA-binding protein 8

Sequence View

        10         20         30         40         50         60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
        70         80         90        100        110        120
SSASELVPPP EETAPTELSK ESTAPAPESI TLHDYTTQPA SQEQPAQPVL QTSTPTSGLL
       130        140        150        160        170        180
QVSKSQEILS QGNPFMGVSA TAVSSSSAGG QPPQSAPKIV ILKAPPSSSV TGAHVAQIQA
       190        200        210        220        230        240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLAAKVPG NQAAVQRIVQ
       250        260        270        280        290        300
PSRPVKQLVL QPVKGSAPAG NPGATGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
       310        320        330        340        350        360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
       370        380        390        400        410        420
QPQPQQPPST QPVTLSSVQQ AQIMGPGQSP GQRLSVPVKV VLQPQAGSSQ GASSGLSVVK
       430        440        450        460        470        480
VLSASEVAAL SSPASSAPHS GGKTGMEENR RLEHQKKQEK ANRIVAEAIA RARARGEQNI
       490        500        510        520        530        540
PRVLNEDELP SVRPEEEGEK KRRKKSAGER LKEEKPKKSK TSGASKTKGK SKLNTITPVV
       550        560        570        580        590        600
GKKRKRNTSS DNSDVEVMPA QSPREDEESS IQKRRSNRQV KRKKYTEDLD IKITDDEEEE
       610        620        630        640        650        660
EVDVTGPIKP EPILPEPVQE PDGETLPSMQ FFVENPSEED AAIVDKVLSM RIVKKELPSG
       670        680        690        700        710        720
QYTEAEEFFV KYKNYSYLHC EWATISQLEK DKRIHQKLKR FKTKMAQMRH FFHEDEEPFN
       730        740        750        760        770        780
PDYVEVDRIL DESHSIDKDN GEPVIYYLVK WCSLPYEDST WELKEDVDEG KIREFKRIQS
       790        800        810        820        830        840
RHPELKRVNR PQASAWKKLE LSHEYKNRNQ LREYQLEGVN WLLFNWYNRQ NCILADEMGL
       850        860        870        880        890        900
GKTIQSIAFL QEVYNVGIHG PFLVIAPLST ITNWEREFNT WTEMNTIVYH GSLASRQMIQ
       910        920        930        940        950        960
QYEMYCKDSR GRLIPGAYKF DALITTFEMI LSDCPELREI EWRCVIIDEA HRLKNRNCKL
       970        980        990       1000       1010       1020
LDSLKHMDLE HKVLLTGTPL QNTVEELFSL LHFLEPSQFP SESEFLKDFG DLKTEEQVQK
      1030       1040       1050       1060       1070       1080
LQAILKPMML RRLKEDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS FLSKGAGHTN
      1090       1100       1110       1120       1130       1140
MPNLLNTMME LRKCCNHPYL INGAEEKILT EFREACHIIP HDFHLQAMVR SAGKLVLIDK
      1150       1160       1170       1180       1190       1200
LLPKLKAGGH KVLIFSQMVR CLDILEDYLI QRRYLYERID GRVRGNLRQA AIDRFSKPDS
      1210       1220       1230       1240       1250       1260
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK AVKVYRLITR
      1270       1280       1290       1300       1310       1320
NSYEREMFDK ASLKLGLDKA VLQSMSGRDG NITGIQQFSK KEIEDLLRKG AYAAIMEEDD
      1330       1340       1350       1360       1370       1380
EGSKFCEEDI DQILLRRTTT ITIESEGKGS TFAKASFVAS ENRTDISLDD PNFWQKWAKK
      1390       1400       1410       1420       1430       1440
ADLDMDLLNS KNNLVIDTPR VRKQTRHFST LKDDDLVEFS DLESEDDERP RSRRHDRHHA
      1450       1460       1470       1480       1490       1500
YGRTDCFRVE KHLLVYGWGR WRDILSHGRF KRRMTERDVE TICRAILVYC LLHYRGDENI
      1510       1520       1530       1540       1550       1560
KGFIWDLISP AENGKTKELQ NHSGLSIPVP RGRKGKKVKS QSTFDIHKAD WIRKYNPDTL
      1570       1580       1590       1600       1610       1620
FQDESYKKHL KHQCNKVLLR VRMLYYLRQE VIGDQAEKVL GGAIASEIDI WFPVVDQLEV
      1630       1640       1650       1660       1670       1680
PTTWWDSEAD KSLLIGVFKH GYEKYNTMRA DPALCFLEKA GRPDDKAIAA EHRVLDNFSD
      1690       1700       1710       1720       1730       1740
IVEGVDFDKD CEDPEYKPLQ GPPKDQDDEG DPLMMMDEEI SVIDGDEAQV TQQPGHLFWP
      1750       1760       1770       1780       1790       1800
PGSALTARLR RLVTAYQRSY KREQMKIEAA ERGDRRRRRC EAAFKLKEIA RREKQQRWTR
      1810       1820       1830       1840       1850       1860
REQTDFYRVV STFGVEYDPD TMQFHWDRFR TFARLDKKTD ESLTKYFHGF VAMCRQVCRL
      1870       1880       1890       1900       1910       1920
PPAAGDEPPD PNLFIEPITE ERASRTLYRI ELLRRLREQV LCHPLLEDRL ALCQPPGPEL
      1930       1940       1950       1960       1970       1980
PKWWEPVRHD GELLRGAARH GVSQTDCNIM QDPDFSFLAA RMNYMQNHQA GAPAPSLSRC
      1990       2000       2010       2020       2030       2040
STPLLHQQYT SRTASPLPLR PDAPVEKSPE ETATQVPSLE SLTLKLEHEV VARSRPTPQD
      2050       2060       2070       2080       2090       2100
YEMRVSPSDT TPLVSRSVPP VKLEDEDDSD SELDLSKLSP SSSSSSSSSS SSSSTDESED
      2110       2120       2130       2140       2150       2160
EKEEKLTDQS RSKLYDEESL LSLTMSQDGF PNEDGEQMTP ELLLLQERQR ASEWPKDRVL
      2170       2180       2190       2200       2210       2220
INRIDLVCQA VLSGKWPSSR RSQEMVTGGI LGPGNHLLDS PSLTPGEYGD SPVPTPRSSS
      2230       2240       2250       2260       2270       2280
AASMAEEEAS AVSTAAAQFT KLRRGMDEKE FTVQIKDEEG LKLTFQKHKL MANGVMGDGH
      2290       2300       2310       2320       2330       2340
PLFHKKKGNR KKLVELEVEC MEEPNHLDVD LETRIPVINK VDGTLLVGED APRRAELEMW
      2350       2360       2370       2380       2390       2400
LQGHPEFAVD PRFLAYMEDR RKQKWQRCKK NNKAELNCLG MEPVQTANSR NGKKGHHTET
      2410       2420       2430       2440       2450       2460
VFNRVLPGPI APESSKKRAR RMRPDLSKMM ALMQGGSTGS LSLHNTFQHS SSGLQSVSSL
      2470       2480       2490       2500       2510       2520
GHSSATSASL PFMPFVMGGA PSSPHVDSST MLHHHHHHPH PHHHHHHHPG LRAPGYPSSP
      2530       2540       2550       2560       2570       2580
VTTASGTTLR LPPLQPEEDD DEDEEDDDDL SQGYDSSERD FSLIDDPMMP ANSDSSEDAD

D

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HCK8-1-unknown	MADPIM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HCK8-377-unknown	SVQQAQ...	377	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172493
Q9HCK8-377-	SVQQAQ...	377		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HCK8-1279-unknown	KAVLQS...	1279	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13361
Q9HCK8-1279-unknown	KAVLQS...	1279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157153
Q9HCK8-1689-unknown	KDCEDP...	1689	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13363
Q9HCK8-1689-unknown	KDCEDP...	1689	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158057
Q9HCK8-2202-unknown	SLTPGE...	2202	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167890
Q9HCK8-2202-	SLTPGE...	2202		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9HCK8-2202-	SLTPGE...	2202		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HCK8-2202-	SLTPGE...	2202		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9HCK8-2202-	SLTPGE...	2202		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9HCK8-2218-unknown	SSSAAS...	2218	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170915
Q9HCK8-2218-	SSSAAS...	2218		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HCK8-2218-	SSSAAS...	2218		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9HCK8-2300-unknown	CMEEPN...	2300	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13365
Q9HCK8-2300-unknown	CMEEPN...	2300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158800

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLGLDK	1278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13361
...KLGLDK	1278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140654
...GVDFDK	1688	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13363
...GVDFDK	1688	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141552
...ELEVEC	2299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13365
...ELEVEC	2299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142304
...EDADD	2581	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDADD	2581	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66139

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1278	GLDK.\|.KAVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	1688	DFDK.\|.KDCE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	2299	EVEC.\|.CMEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

TopFIND

Q9HCK8: Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071}

General Information

10

N-termini

4

C-termini

3

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates