Q9NVP1: ATP-dependent RNA helicase DDX18

General Information

Protein names	- ATP-dependent RNA helicase DDX18 - 3.6.4.13 - DEAD box protein 18 - Myc-regulated DEAD box protein - MrDb
Gene names	DDX18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NVP1

11 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHLPMKLLR KKIEKRNLKL RQRNLKFQGA SNLTLSETQN GDVSEETMGS RKVKKSKQKP
        70         80         90        100        110        120
MNVGLSETQN GGMSQEAVGN IKVTKSPQKS TVLTNGEAAM QSSNSESKKK KKKKRKMVND
       130        140        150        160        170        180
AEPDTKKAKT ENKGKSEEES AETTKETENN VEKPDNDEDE SEVPSLPLGL TGAFEDTSFA
       190        200        210        220        230        240
SLCNLVNENT LKAIKEMGFT NMTEIQHKSI RPLLEGRDLL AAAKTGSGKT LAFLIPAVEL
       250        260        270        280        290        300
IVKLRFMPRN GTGVLILSPT RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEAQKLGN
       310        320        330        340        350        360
GINIIVATPG RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI IKLLPTRRQT
       370        380        390        400        410        420
MLFSATQTRK VEDLARISLK KEPLYVGVDD DKANATVDGL EQGYVVCPSE KRFLLLFTFL
       430        440        450        460        470        480
KKNRKKKLMV FFSSCMSVKY HYELLNYIDL PVLAIHGKQK QNKRTTTFFQ FCNADSGTLL
       490        500        510        520        530        540
CTDVAARGLD IPEVDWIVQY DPPDDPKEYI HRVGRTARGL NGRGHALLIL RPEELGFLRY
       550        560        570        580        590        600
LKQSKVPLSE FDFSWSKISD IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN
       610        620        630        640        650        660
VNNLNLPQVA LSFGFKVPPF VDLNVNSNEG KQKKRGGGGG FGYQKTKKVE KSKIFKHISK
       670
KSSDSRQFSH

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NVP1-1-unknown	MSHLPM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NVP1-34-unknown	TLSETQ...	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15054
Q9NVP1-36-	SETQNG...	36		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NVP1-37-unknown	ETQNGD...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15055
Q9NVP1-39-unknown	QNGDVS...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15056
Q9NVP1-58-unknown	QKPMNV...	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15057
Q9NVP1-66-	SETQNG...	66		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NVP1-66-unknown	SETQNG...	66		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NVP1-125-unknown	TKKAKT...	125	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13418
Q9NVP1-209-	SIRPLL...	209		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NVP1-318-unknown	NTPGFM...	318	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415604

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GASNLT	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15054
...NLTLSE	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15055
...TLSETQ	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15056
...VKKSKQ	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15057
...DAEPDT	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13418
...VPLSEF	550	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415604
...RQFSH	670	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	33	SNLT.\|.TLSE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	36	TLSE.\|.ETQN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	38	SETQ.\|.QNGD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	57	KSKQ.\|.QKPM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	124	EPDT.\|.TKKA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)