Q9NY61: Protein AATF

General Information

Protein names	- Protein AATF - Apoptosis-antagonizing transcription factor - Rb-binding protein Che-1
Gene names	AATF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NY61

9 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGPQPLALQ LEQLLNPRPS EADPEADPEE ATAARVIDRF DEGEDGEGDF LVVGSIRKLA
        70         80         90        100        110        120
SASLLDTDKR YCGKTTSRKA WNEDHWEQTL PGSSDEEISD EEGSGDEDSE GLGLEEYDED
       130        140        150        160        170        180
DLGAAEEQEC GDHRESKKSR SHSAKTPGFS VQSISDFEKF TKGMDDLGSS EEEEDEESGM
       190        200        210        220        230        240
EEGDDAEDSQ GESEEDRAGD RNSEDDGVVM TFSSVKVSEE VEKGRAVKNQ IALWDQLLEG
       250        260        270        280        290        300
RIKLQKALLT TNQLPQPDVF PLFKDKGGPE FSSALKNSHK ALKALLRSLV GLQEELLFQY
       310        320        330        340        350        360
PDTRYLVDGT KPNAGSEEIS SEDDELVEEK KQQRRRVPAK RKLEMEDYPS FMAKRFADFT
       370        380        390        400        410        420
VYRNRTLQKW HDKTKLASGK LGKGFGAFER SILTQIDHIL MDKERLLRRT QTKRSVYRVL
       430        440        450        460        470        480
GKPEPAAQPV PESLPGEPEI LPQAPANAHL KDLDEEIFDD DDFYHQLLRE LIERKTSSLD
       490        500        510        520        530        540
PNDQVAMGRQ WLAIQKLRSK IHKKVDRKAS KGRKLRFHVL SKLLSFMAPI DHTTMNDDAR
       550        560
TELYRSLFGQ LHPPDEGHGD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NY61-2-unknown	MAGPQP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NY61-2-Acetylation	AGPQPL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NY61-2-Acetylation	AGPQPL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NY61-50-unknown	FLVVGS...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13435
Q9NY61-61-	SASLLD...	61			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NY61-153-	SISDFE...	153			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NY61-153-	SISDFE...	153			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NY61-309-	GTKPNA...	309			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NY61-314-unknown	AGSEEI...	314		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13436
Q9NY61-363-unknown	RNRTLQ...	363		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468195
Q9NY61-433-unknown	SLPGEP...	433		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13437

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DGEGDF	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13435
...GTKPNA	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13436
...QPVPES	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13437
...GRKLRF	516	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468195
...EGHGD	560	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	49	EGDF.\|.FLVV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	313	KPNA.\|.AGSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	432	VPES.\|.SLPG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)