Q9NZM5: Ribosome biogenesis protein NOP53 {ECO:0000305}

General Information

Protein names	- Ribosome biogenesis protein NOP53 {ECO:0000305} - Glioma tumor suppressor candidate region gene 2 protein {ECO:0000312\|HGNC:HGNC:4333} - Protein interacting with carboxyl terminus 1 {ECO:0000303\|PubMed:15355975} - PICT-1 {ECO:0000303\|PubMed:15355975} - p60 {ECO:0000303\|PubMed:10196275}
Gene names	GLTSCR2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZM5

9 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGGSGVGG KRSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR LAQEPLGLEV
        70         80         90        100        110        120
DQFLEDVRLQ ERTSGGLLSE APNEKLFFVD TGSKEKGLTK KRTKVQKKSL LLKKPLRVDL
       130        140        150        160        170        180
ILENTSKVPA PKDVLAHQVP NAKKLRRKEQ LWEKLAKQGE LPREVRRAQA RLLNPSATRA
       190        200        210        220        230        240
KPGPQDTVER PFYDLWASDN PLDRPLVGQD EFFLEQTKKK GVKRPARLHT KPSQAPAVEV
       250        260        270        280        290        300
APAGASYNPS FEDHQTLLSA AHEVELQRQK EAEKLERQLA LPATEQAATQ ESTFQELCEG
       310        320        330        340        350        360
LLEESDGEGE PGQGEGPEAG DAEVCPTPAR LATTEKKTEQ QRRREKAVHR LRVQQAALRA
       370        380        390        400        410        420
ARLRHQELFR LRGIKAQVAL RLAELARRQR RRQARREAEA DKPRRLGRLK YQAPDIDVQL
       430        440        450        460        470
SSELTDSLRT LKPEGNILRD RFKSFQRRNM IEPRERAKFK RKYKVKLVEK RAFREIQL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZM5-2-unknown	MAAGGS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZM5-2-	AAGGSG...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NZM5-2-	AAGGSG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NZM5-2-	AAGGSG...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NZM5-2-Acetylation	AAGGSG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZM5-2-Acetylation	AAGGSG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NZM5-2-Acetylation	AAGGSG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NZM5-25-unknown	LRPTSV...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13473
Q9NZM5-25-unknown	LRPTSV...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15080
Q9NZM5-57-unknown	GLEVDQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15081
Q9NZM5-62-unknown	QFLEDV...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13474
Q9NZM5-120-unknown	LILENT...	120		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470263
Q9NZM5-322-unknown	AEVCPT...	322		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13475
Q9NZM5-394-unknown	ARREAE...	394		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470773

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGFLGL	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13473
...SGFLGL	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15080
...AQEPLG	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15081
...GLEVDQ	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13474
...PEAGDA	321	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13475
...REIQL	478	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	24	FLGL.\|.LRPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	24	FLGL.\|.LRPT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	56	EPLG.\|.GLEV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	61	EVDQ.\|.QFLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	321	AGDA.\|.AEVC	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)