Q9P2J5: Leucine--tRNA ligase, cytoplasmic

General Information

Protein names	- Leucine--tRNA ligase, cytoplasmic - 6.1.1.4 - Leucyl-tRNA synthetase - LeuRS
Gene names	LARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9P2J5

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH
        70         80         90        100        110        120
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC ADKLKREIEL YGCPPDFPDE
       130        140        150        160        170        180
EEEEEETSVK TEDIIIKDKA KGKKSKAAAK AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW
       190        200        210        220        230        240
LDYFPPLAIQ DLKRMGLKVD WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY
       250        260        270        280        290        300
SPKDGQPCMD HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF
       310        320        330        340        350        360
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK ELMGEEILGA
       370        380        390        400        410        420
SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI AALRDLKKKQ ALRAKYGIRD
       430        440        450        460        470        480
DMVLPFEPVP VIEIPGFGNL SAVTICDELK IQSQNDREKL AEAKEKIYLK GFYEGIMLVD
       490        500        510        520        530        540
GFKGQKVQDV KKTIQKKMID AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK
       550        560        570        580        590        600
KQTSQCLKNL ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY
       610        620        630        640        650        660
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI AKEKLDQLKQ
       670        680        690        700        710        720
EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW PTAVRANGHL LLNSEKMSKS
       730        740        750        760        770        780
TGNFLTLTQA IDKFSADGMR LALADAGDTV EDANFVEAMA DAGILRLYTW VEWVKEMVAN
       790        800        810        820        830        840
WDSLRSGPAS TFNDRVFASE LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV
       850        860        870        880        890        900
EGMHRELVFR FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ
       910        920        930        940        950        960
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT TLSVLRKHFE
       970        980        990       1000       1010       1020
ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL EKMGPRILDL QLEFDEKAVL
      1030       1040       1050       1060       1070       1080
MENIVYLTNS LELEHIEVKF ASEAEDKIRE DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH
      1090       1100       1110       1120       1130       1140
FSTKIEIRQG DNCDSIIRRL MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP
      1150       1160       1170
ISEHAVFNVD LMSKKIHLTE NGIRVDIGDT IIYLVH

Isoforms

- Isoform 2 of Leucine--tRNA ligase, cytoplasmic - Isoform 3 of Leucine--tRNA ligase, cytoplasmic

Sequence View

        10         20         30         40         50         60
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH
        70         80         90        100        110        120
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC ADKLKREIEL YGCPPDFPDE
       130        140        150        160        170        180
EEEEEETSVK TEDIIIKDKA KGKKSKAAAK AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW
       190        200        210        220        230        240
LDYFPPLAIQ DLKRMGLKVD WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY
       250        260        270        280        290        300
SPKDGQPCMD HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF
       310        320        330        340        350        360
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK ELMGEEILGA
       370        380        390        400        410        420
SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI AALRDLKKKQ ALRAKYGIRD
       430        440        450        460        470        480
DMVLPFEPVP VIEIPGFGNL SAVTICDELK IQSQNDREKL AEAKEKIYLK GFYEGIMLVD
       490        500        510        520        530        540
GFKGQKVQDV KKTIQKKMID AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK
       550        560        570        580        590        600
KQTSQCLKNL ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY
       610        620        630        640        650        660
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI AKEKLDQLKQ
       670        680        690        700        710        720
EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW PTAVRANGHL LLNSEKMSKS
       730        740        750        760        770        780
TGNFLTLTQA IDKFSADGMR LALADAGDTV EDANFVEAMA DAGILRLYTW VEWVKEMVAN
       790        800        810        820        830        840
WDSLRSGPAS TFNDRVFASE LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV
       850        860        870        880        890        900
EGMHRELVFR FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ
       910        920        930        940        950        960
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT TLSVLRKHFE
       970        980        990       1000       1010       1020
ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL EKMGPRILDL QLEFDEKAVL
      1030       1040       1050       1060       1070       1080
MENIVYLTNS LELEHIEVKF ASEAEDKIRE DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH
      1090       1100       1110       1120       1130       1140
FSTKIEIRQG DNCDSIIRRL MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP
      1150       1160       1170
ISEHAVFNVD LMSKKIHLTE NGIRVDIGDT IIYLVH         10         20         30         40         50         60
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH
        70         80         90        100        110        120
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC ADKLKREIEL YGCPPDFPDE
       130        140        150        160        170        180
EEEEEETSVK TEDIIIKDKA KGKKSKAAAK AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW
       190        200        210        220        230        240
LDYFPPLAIQ DLKRMGLKVD WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY
       250        260        270        280        290        300
SPKDGQPCMD HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF
       310        320        330        340        350        360
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK ELMGEEILGA
       370        380        390        400        410        420
SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI AALRDLKKKQ ALRAKYGIRD
       430        440        450        460        470        480
DMVLPFEPVP VIEIPGFGNL SAVTICDELK IQSQNDREKL AEAKEKIYLK GFYEGIMLVD
       490        500        510        520        530        540
GFKGQKVQDV KKTIQKKMID AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK
       550        560        570        580        590        600
KQTSQCLKNL ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY
       610        620        630        640        650        660
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI AKEKLDQLKQ
       670        680        690        700        710        720
EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW PTAVRANGHL LLNSEKMSKS
       730        740        750        760        770        780
TGNFLTLTQA IDKFSADGMR LALADAGDTV EDANFVEAMA DAGILRLYTW VEWVKEMVAN
       790        800        810        820        830        840
WDSLRSGPAS TFNDRVFASE LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV
       850        860        870        880        890        900
EGMHRELVFR FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ
       910        920        930        940        950        960
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT TLSVLRKHFE
       970        980        990       1000       1010       1020
ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL EKMGPRILDL QLEFDEKAVL
      1030       1040       1050       1060       1070       1080
MENIVYLTNS LELEHIEVKF ASEAEDKIRE DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH
      1090       1100       1110       1120       1130       1140
FSTKIEIRQG DNCDSIIRRL MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP
      1150       1160       1170
ISEHAVFNVD LMSKKIHLTE NGIRVDIGDT IIYLVH

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9P2J5-1-unknown	MAERKG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9P2J5-55-unknown	MNGRLH...	55	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426005
Q9P2J5-163-	SLGLSD...	163		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9P2J5-498-	MIDAGD...	498		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9P2J5-498-	MIDAGD...	498		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9P2J5-498-	MIDAGD...	498		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9P2J5-498-	MIDAGD...	498		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9P2J5-498-	MIDAGD...	498		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9P2J5-504-	ALIYME...	504		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9P2J5-504-	ALIYME...	504		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9P2J5-504-	ALIYME...	504		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9P2J5-504-unknown	ALIYME...	504	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13489
Q9P2J5-508-	MEPEKQ...	508		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IDAGDA	503	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13489
...IYLVH	1176	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...IYLVH	1176		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IYLVH	1176		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...IYLVH	1176		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IYLVH	1176		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

TopFIND

Q9P2J5: Leucine--tRNA ligase, cytoplasmic

General Information

7

N-termini

3

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates