Q9UER7: Death domain-associated protein 6

General Information

Protein names	- Death domain-associated protein 6 - Daxx - hDaxx - ETS1-associated protein 1 - EAP1 - Fas death domain-associated protein
Gene names	DAXX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UER7

10 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Death domain-associated protein 6 - Isoform 3 of Death domain-associated protein 6 - Isoform beta of Death domain-associated protein 6 - Isoform gamma of Death domain-associated protein 6

Sequence View

        10         20         30         40         50         60
MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK
        70         80         90        100        110        120
LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP
       130        140        150        160        170        180
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR
       190        200        210        220        230        240
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC
       250        260        270        280        290        300
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
       310        320        330        340        350        360
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR
       370        380        390        400        410        420
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS
       430        440        450        460        470        480
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE
       490        500        510        520        530        540
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP
       550        560        570        580        590        600
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
       610        620        630        640        650        660
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
       670        680        690        700        710        720
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC
       730        740
KTSVATQCDP EEIIVLSDSD         10         20         30         40         50         60
MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK
        70         80         90        100        110        120
LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP
       130        140        150        160        170        180
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR
       190        200        210        220        230        240
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC
       250        260        270        280        290        300
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
       310        320        330        340        350        360
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR
       370        380        390        400        410        420
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS
       430        440        450        460        470        480
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE
       490        500        510        520        530        540
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP
       550        560        570        580        590        600
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
       610        620        630        640        650        660
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
       670        680        690        700        710        720
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC
       730        740
KTSVATQCDP EEIIVLSDSD         10         20         30         40         50         60
MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK
        70         80         90        100        110        120
LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP
       130        140        150        160        170        180
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR
       190        200        210        220        230        240
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC
       250        260        270        280        290        300
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
       310        320        330        340        350        360
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR
       370        380        390        400        410        420
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS
       430        440        450        460        470        480
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE
       490        500        510        520        530        540
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP
       550        560        570        580        590        600
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
       610        620        630        640        650        660
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
       670        680        690        700        710        720
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC
       730        740
KTSVATQCDP EEIIVLSDSD         10         20         30         40         50         60
MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK
        70         80         90        100        110        120
LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP
       130        140        150        160        170        180
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR
       190        200        210        220        230        240
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC
       250        260        270        280        290        300
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH
       310        320        330        340        350        360
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR
       370        380        390        400        410        420
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS
       430        440        450        460        470        480
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE
       490        500        510        520        530        540
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP
       550        560        570        580        590        600
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV
       610        620        630        640        650        660
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG
       670        680        690        700        710        720
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC
       730        740
KTSVATQCDP EEIIVLSDSD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UER7-1-unknown	MATANS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UER7-1-unknown	MATANS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72353
Q9UER7-76-unknown	MQTADH...	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72354
Q9UER7-76-unknown	MQTADH...	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104911
Q9UER7-165-unknown	SLDPTN...	165	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15087
Q9UER7-165-unknown	SLDPTN...	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141850
Q9UER7-165-unknown	SLDPTN...	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145357
Q9UER7-170-unknown	NAENTA...	170	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15090
Q9UER7-170-unknown	NAENTA...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142152
Q9UER7-170-unknown	NAENTA...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145547
Q9UER7-220-	SAYLQE...	220		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UER7-220-unknown	SAYLQE...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174401
Q9UER7-220-unknown	SAYLQE...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174402
Q9UER7-415-unknown	SGEGPS...	415	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13509
Q9UER7-415-unknown	SGEGPS...	415	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150743
Q9UER7-415-unknown	SGEGPS...	415	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152255
Q9UER7-498-unknown	SSLQIS...	498	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15093
Q9UER7-498-unknown	SSLQIS...	498	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152397
Q9UER7-498-unknown	SSLQIS...	498	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153394
Q9UER7-573-unknown	ALPLDT...	573	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167209
Q9UER7-573-unknown	ALPLDT...	573	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167210
Q9UER7-573-	ALPLDT...	573		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPTHLS	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15087
...PPTHLS	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125029
...PPTHLS	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128649
...SLDPTN	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15090
...SLDPTN	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125338
...SLDPTN	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128845
...EASLDS	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13509
...EASLDS	414	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134142
...EASLDS	414	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135665
...DKSPMS	497	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15093
...DKSPMS	497	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135808
...DKSPMS	497	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136818
...LSDSD	740	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LSDSD	740	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67972

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	164	THLS.\|.SLDP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	169	DPTN.\|.NAEN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	414	SLDS.\|.SGEG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	497	SPMS.\|.SSLQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)