Q9UG63: ATP-binding cassette sub-family F member 2

General Information

Protein names	- ATP-binding cassette sub-family F member 2 - Iron-inhibited ABC transporter 2
Gene names	ABCF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UG63

11 N-termini

8 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL
        70         80         90        100        110        120
EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN
       130        140        150        160        170        180
GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA
       190        200        210        220        230        240
HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA
       250        260        270        280        290        300
RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN
       310        320        330        340        350        360
KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE
       370        380        390        400        410        420
KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI
       430        440        450        460        470        480
DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL
       490        500        510        520        530        540
EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL
       550        560        570        580        590        600
DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA
       610        620
YKEHLKSKLV DEEPQLTKRT HNV

Isoforms

- Isoform 2 of ATP-binding cassette sub-family F member 2

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UG63-1-unknown	MPSDLA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UG63-1-unknown	MPSDLA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65989
Q9UG63-2-unknown	PSDLAK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UG63-2-unknown	PSDLAK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UG63-2-unknown	PSDLAK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162436
Q9UG63-39-unknown	VAEKNE...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15096
Q9UG63-39-unknown	VAEKNE...	39	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138290
Q9UG63-52-unknown	EVDLLT...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15098
Q9UG63-52-unknown	EVDLLT...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139364
Q9UG63-55-unknown	LLTKEL...	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13514
Q9UG63-55-unknown	LLTKEL...	55	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139555
Q9UG63-57-unknown	TKELED...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15100
Q9UG63-57-unknown	TKELED...	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139711
Q9UG63-366-unknown	MMASGL...	366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169769
Q9UG63-366-	MMASGL...	366		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UG63-366-	MMASGL...	366		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UG63-503-	YGLTGK...	503		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UG63-503-unknown	YGLTGK...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169767
Q9UG63-506-unknown	TGKQQV...	506	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15102
Q9UG63-506-unknown	TGKQQV...	506	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153494

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VTEPQV	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15096
...VTEPQV	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121323
...GRETTE	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15098
...GRETTE	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122442
...TTEVDL	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13514
...TTEVDL	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122647
...EVDLLT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15100
...EVDLLT	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122810
...RVALAR	240	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395785
...RVALAR	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108444
...HSQDFL	287	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419720
...HSQDFL	287	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108442
...GRYGLT	505	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15102
...GRYGLT	505	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136917
...RTHNV	623	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RTHNV	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93156

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	38	EPQV.\|.VAEK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	51	ETTE.\|.EVDL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	54	EVDL.\|.LLTK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	56	DLLT.\|.TKEL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	505	YGLT.\|.TGKQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)