Q9UNF1: Melanoma-associated antigen D2

General Information

Protein names	- Melanoma-associated antigen D2 - 11B6 - Breast cancer-associated gene 1 protein - BCG-1 - Hepatocellular carcinoma-associated protein JCL-1 - MAGE-D2 antigen
Gene names	MAGED2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UNF1

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDTSESGAG LTRFQAEASE KDSSSMMQTL LTVTQNVEVP ETPKASKALE VSEDVKVSKA
        70         80         90        100        110        120
SGVSKATEVS KTPEAREAPA TQASSTTQLT DTQVLAAENK SLAADTKKQN ADPQAVTMPA
       130        140        150        160        170        180
TETKKVSHVA DTKVNTKAQE TEAAPSQAPA DEPEPESAAA QSQENQDTRP KVKAKKARKV
       190        200        210        220        230        240
KHLDGEEDGS SDQSQASGTT GGRRVSKALM ASMARRASRG PIAFWARRAS RTRLAAWARR
       250        260        270        280        290        300
ALLSLRSPKA RRGKARRRAA KLQSSQEPEA PPPRDVALLQ GRANDLVKYL LAKDQTKIPI
       310        320        330        340        350        360
KRSDMLKDII KEYTDVYPEI IERAGYSLEK VFGIQLKEID KNDHLYILLS TLEPTDAGIL
       370        380        390        400        410        420
GTTKDSPKLG LLMVLLSIIF MNGNRSSEAV IWEVLRKLGL RPGIHHSLFG DVKKLITDEF
       430        440        450        460        470        480
VKQKYLDYAR VPNSNPPEYE FFWGLRSYYE TSKMKVLKFA CKVQKKDPKE WAAQYREAME
       490        500        510        520        530        540
ADLKAAAEAA AEAKARAEIR ARMGIGLGSE NAAGPCNWDE ADIGPWAKAR IQAGAEAKAK
       550        560        570        580        590        600
AQESGSASTG ASTSTNNSAS ASASTSGGFS AGASLTATLT FGLFAGLGGA GASTSGSSGA

CGFSYK

Isoforms

- Isoform 2 of Melanoma-associated antigen D2

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UNF1-2-unknown	MSDTSE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UNF1-1-unknown	MSDTSE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80308
Q9UNF1-2-Acetylation	SDTSES...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UNF1-2-Acetylation	SDTSES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UNF1-2-Acetylation	SDTSES...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9UNF1-2-Acetylation	SDTSES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UNF1-2-Acetylation	SDTSES...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110523
Q9UNF1-23-	SSSMMQ...	23			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UNF1-23-	SSSMMQ...	23			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UNF1-23-	SSSMMQ...	23			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNF1-23-unknown	SSSMMQ...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175382
Q9UNF1-92-unknown	TQVLAA...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13548
Q9UNF1-92-unknown	TQVLAA...	92		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140941
Q9UNF1-143-	AAPSQA...	143			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UNF1-143-	AAPSQA...	143			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNF1-143-unknown	AAPSQA...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176847
Q9UNF1-158-unknown	AAAQSQ...	158		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8151
Q9UNF1-158-unknown	AAAQSQ...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144322

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TQLTDT	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13548
...TQLTDT	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124085
...PEPESA	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8151
...PEPESA	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127584
...GFSYK	606	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GFSYK	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75926

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	91	LTDT.\|.TQVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	157	PESA.\|.AAAQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)