Q9UNS1: Protein timeless homolog
Protein names | - Protein timeless homolog - hTIM |
---|---|
Gene names | TIMELESS |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9UNS1 |
5
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI
70 80 90 100 110 120
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY
130 140 150 160 170 180
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID
190 200 210 220 230 240
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG
250 260 270 280 290 300
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG
310 320 330 340 350 360
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS
370 380 390 400 410 420
VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE
430 440 450 460 470 480
MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE
490 500 510 520 530 540
LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL
550 560 570 580 590 600
DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM
610 620 630 640 650 660
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL SAPLPRQQGP
670 680 690 700 710 720
EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC STVVRAYVLL LRSYQQNSAH
730 740 750 760 770 780
TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL FNRLLSDPAA GAYKELVTFA KYILGKFFAL
790 800 810 820 830 840
AAVNQKAFVE LLFWKNTAVV REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV
850 860 870 880 890 900
EGQDVVEAIL AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL
910 920 930 940 950 960
FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK LASSILPNGA
970 980 990 1000 1010 1020
ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV LSNENLGQSL HQEGFSIPLL
1030 1040 1050 1060 1070 1080
WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE NEEAMENEQF QQLLRKLGVR PPASGQETFW
1090 1100 1110 1120 1130 1140
RIPAKLSPTQ LRRAAASLSQ PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA
1150 1160 1170 1180 1190 1200
HKKKAGLASP EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY
QIEDDEDD
Isoforms
- Isoform 2 of Protein timeless homologSequence View
10 20 30 40 50 60
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI
70 80 90 100 110 120
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY
130 140 150 160 170 180
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID
190 200 210 220 230 240
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG
250 260 270 280 290 300
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG
310 320 330 340 350 360
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS
370 380 390 400 410 420
VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE
430 440 450 460 470 480
MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE
490 500 510 520 530 540
LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL
550 560 570 580 590 600
DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM
610 620 630 640 650 660
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL SAPLPRQQGP
670 680 690 700 710 720
EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC STVVRAYVLL LRSYQQNSAH
730 740 750 760 770 780
TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL FNRLLSDPAA GAYKELVTFA KYILGKFFAL
790 800 810 820 830 840
AAVNQKAFVE LLFWKNTAVV REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV
850 860 870 880 890 900
EGQDVVEAIL AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL
910 920 930 940 950 960
FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK LASSILPNGA
970 980 990 1000 1010 1020
ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV LSNENLGQSL HQEGFSIPLL
1030 1040 1050 1060 1070 1080
WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE NEEAMENEQF QQLLRKLGVR PPASGQETFW
1090 1100 1110 1120 1130 1140
RIPAKLSPTQ LRRAAASLSQ PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA
1150 1160 1170 1180 1190 1200
HKKKAGLASP EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY
QIEDDEDD
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9UNS1-1-unknown | MDLHMM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9UNS1-1-unknown | MDLHMM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92183 | |||
Q9UNS1-6-unknown | MNCELL... | 6 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q9UNS1-6-unknown | MNCELL... | 6 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt194699 | |||
Q9UNS1-580- | SVVPFD... | 580 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9UNS1-580- | SVVPFD... | 580 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q9UNS1-580- | SVVPFD... | 580 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9UNS1-580- | SVVPFD... | 580 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9UNS1-580-unknown | SVVPFD... | 580 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171865 | |||
Q9UNS1-1148-unknown | ASPEEE... | 1148 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15123 | |||
Q9UNS1-1148-unknown | ASPEEE... | 1148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157495 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KKAGLA | 1147 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15123 | |||
...KKAGLA | 1147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140993 | |||
...DDEDD | 1208 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...DDEDD | 1208 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87801 | |||
...DDEDD | 1208 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...DDEDD | 1208 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 1147 | AGLA.|.ASPE | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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