Q9UPW5: Cytosolic carboxypeptidase 1

General Information

Protein names	- Cytosolic carboxypeptidase 1 - 3.4.17.- - ATP/GTP-binding protein 1 - Nervous system nuclear protein induced by axotomy protein 1 homolog
Gene names	AGTPBP1
Organism	Homo sapiens
Protease Family	M14.028
Protease ID	M14.028
Chromosome location
UniProt ID	Q9UPW5

2 N-termini

1 C-termini

0 Cleavages

5 Substrates

Sequence

        10         20         30         40         50         60
MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT
        70         80         90        100        110        120
AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN
       130        140        150        160        170        180
ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL
       190        200        210        220        230        240
QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA
       250        260        270        280        290        300
VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN
       310        320        330        340        350        360
TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPVIPVT GPVAQLYSLP
       370        380        390        400        410        420
PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE TDINKLKPQQ EPGRTIEDLK
       430        440        450        460        470        480
MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT AGEETSGNSG NLRKVVMKEN
       490        500        510        520        530        540
ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI SSVHGLNNDI VKALDRITLQ
       550        560        570        580        590        600
NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV LFEGRTVQLG KLCCTGVETE
       610        620        630        640        650        660
DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV PEYSEVAYPD YFGHIPPPFK
       670        680        690        700        710        720
EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN YTIPEEGDIL KFNSKFESGN
       730        740        750        760        770        780
LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV AYRFNIINCE KSNSQFNYGM
       790        800        810        820        830        840
QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG QKGKSYYTIT FTVNFPHKDD
       850        860        870        880        890        900
VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE TLSGNSCPLV TITAMPESNY
       910        920        930        940        950        960
YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN NPTAQSLRES YIFKIVPMLN
       970        980        990       1000       1010       1020
PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL QYLAAVKRLP LVYCDYHGHS
      1030       1040       1050       1060       1070       1080
RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI LSHIAPAFCM SSCSFVVEKS
      1090       1100       1110       1120       1130       1140
KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT RELEEMGAKF CVGLLRLKRL
      1150       1160       1170       1180       1190       1200
TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR FLEEVDYSAE SNDELDIELA
      1210       1220
ENVGDYEPSA QEEVLSDSEL SRTYLP

Isoforms

- Isoform 2 of Cytosolic carboxypeptidase 1 - Isoform 3 of Cytosolic carboxypeptidase 1

Sequence View

        10         20         30         40         50         60
MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT
        70         80         90        100        110        120
AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN
       130        140        150        160        170        180
ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL
       190        200        210        220        230        240
QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA
       250        260        270        280        290        300
VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN
       310        320        330        340        350        360
TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPVIPVT GPVAQLYSLP
       370        380        390        400        410        420
PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE TDINKLKPQQ EPGRTIEDLK
       430        440        450        460        470        480
MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT AGEETSGNSG NLRKVVMKEN
       490        500        510        520        530        540
ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI SSVHGLNNDI VKALDRITLQ
       550        560        570        580        590        600
NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV LFEGRTVQLG KLCCTGVETE
       610        620        630        640        650        660
DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV PEYSEVAYPD YFGHIPPPFK
       670        680        690        700        710        720
EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN YTIPEEGDIL KFNSKFESGN
       730        740        750        760        770        780
LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV AYRFNIINCE KSNSQFNYGM
       790        800        810        820        830        840
QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG QKGKSYYTIT FTVNFPHKDD
       850        860        870        880        890        900
VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE TLSGNSCPLV TITAMPESNY
       910        920        930        940        950        960
YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN NPTAQSLRES YIFKIVPMLN
       970        980        990       1000       1010       1020
PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL QYLAAVKRLP LVYCDYHGHS
      1030       1040       1050       1060       1070       1080
RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI LSHIAPAFCM SSCSFVVEKS
      1090       1100       1110       1120       1130       1140
KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT RELEEMGAKF CVGLLRLKRL
      1150       1160       1170       1180       1190       1200
TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR FLEEVDYSAE SNDELDIELA
      1210       1220
ENVGDYEPSA QEEVLSDSEL SRTYLP         10         20         30         40         50         60
MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT
        70         80         90        100        110        120
AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN
       130        140        150        160        170        180
ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL
       190        200        210        220        230        240
QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA
       250        260        270        280        290        300
VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN
       310        320        330        340        350        360
TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPVIPVT GPVAQLYSLP
       370        380        390        400        410        420
PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE TDINKLKPQQ EPGRTIEDLK
       430        440        450        460        470        480
MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT AGEETSGNSG NLRKVVMKEN
       490        500        510        520        530        540
ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI SSVHGLNNDI VKALDRITLQ
       550        560        570        580        590        600
NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV LFEGRTVQLG KLCCTGVETE
       610        620        630        640        650        660
DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV PEYSEVAYPD YFGHIPPPFK
       670        680        690        700        710        720
EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN YTIPEEGDIL KFNSKFESGN
       730        740        750        760        770        780
LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV AYRFNIINCE KSNSQFNYGM
       790        800        810        820        830        840
QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG QKGKSYYTIT FTVNFPHKDD
       850        860        870        880        890        900
VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE TLSGNSCPLV TITAMPESNY
       910        920        930        940        950        960
YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN NPTAQSLRES YIFKIVPMLN
       970        980        990       1000       1010       1020
PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL QYLAAVKRLP LVYCDYHGHS
      1030       1040       1050       1060       1070       1080
RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI LSHIAPAFCM SSCSFVVEKS
      1090       1100       1110       1120       1130       1140
KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT RELEEMGAKF CVGLLRLKRL
      1150       1160       1170       1180       1190       1200
TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR FLEEVDYSAE SNDELDIELA
      1210       1220
ENVGDYEPSA QEEVLSDSEL SRTYLP

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UPW5-1-unknown	MSKLKV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UPW5-1-unknown	MSKLKV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69433
Q9UPW5-2-acetylation	SKLKVI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UPW5-2-acetylation	SKLKVI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178698

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RTYLP	1226	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RTYLP	1226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65051
...RTYLP	1226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65052

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
TBA8-Isoform2_HUMAN	382	GEEF.\|.F	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8293
TBA3C-Isoform2_HUMAN	417	GEEY.\|.Y	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8290
TBA1C_HUMAN	448	GEEY.\|.Y	inferred from experiment	unknown	MEROPS	Merops CBPC1_HUMAN -> TBA1C_HUMAN @448
TBA8_HUMAN	448	GEEF.\|.F	inferred from experiment	unknown	MEROPS	Merops CBPC1_HUMAN -> TBA8_HUMAN @448
TBA3C_HUMAN	449	GEEY.\|.Y	inferred from experiment	unknown	MEROPS	Merops CBPC1_HUMAN -> TBA3C_HUMAN @449

TopFIND

Q9UPW5: Cytosolic carboxypeptidase 1

General Information

2

N-termini

1

C-termini

0

Cleavages

5

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 5 Substrates

N-termini

C-termini

Cleavages

Substrates