Q9BQE3: Tubulin alpha-1C chain

General Information

Protein names	- Tubulin alpha-1C chain - Alpha-tubulin 6 - Tubulin alpha-6 chain - Detyrosinated tubulin alpha-1C chain
Gene names	TUBA1C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQE3

31 N-termini

33 C-termini

32 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK
        70         80         90        100        110        120
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD
       130        140        150        160        170        180
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
       190        200        210        220        230        240
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA
       250        260        270        280        290        300
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLTVAE ITNACFEPAN
       310        320        330        340        350        360
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP
       370        380        390        400        410        420
TVVPGGDLAK VQRAVCMLSN TTAVAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
       430        440
AREDMAALEK DYEEVGADSA DGEDEGEEY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

31 N-termini - 33 C-termini - 32 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BQE3-1-unknown	MRECIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BQE3-41-unknown	TIGGGD...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10511
Q9BQE3-57-unknown	GAGKHV...	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15498
Q9BQE3-65-unknown	AVFVDL...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10512
Q9BQE3-66-unknown	VFVDLE...	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15499
Q9BQE3-67-unknown	FVDLEP...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15500
Q9BQE3-69-unknown	DLEPTV...	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15501
Q9BQE3-70-unknown	LEPTVI...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15502
Q9BQE3-71-unknown	EPTVID...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13161
Q9BQE3-85-unknown	QLFHPE...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10513
Q9BQE3-91-unknown	QLITGK...	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13162
Q9BQE3-93-unknown	ITGKED...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15503
Q9BQE3-136-unknown	LVFHSF...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14913
Q9BQE3-138-unknown	FHSFGG...	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15504
Q9BQE3-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14914
Q9BQE3-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15505
Q9BQE3-205-unknown	DNEAIY...	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15506
Q9BQE3-206-unknown	NEAIYD...	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13163
Q9BQE3-208-unknown	AIYDIC...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13164
Q9BQE3-252-unknown	LTEFQT...	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13165
Q9BQE3-254-unknown	EFQTNL...	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15507
Q9BQE3-287-unknown	TVAEIT...	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14915
Q9BQE3-292-unknown	TNACFE...	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15508
Q9BQE3-329-unknown	NAAIAT...	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15509
Q9BQE3-353-unknown	VGINYQ...	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10514
Q9BQE3-354-unknown	GINYQP...	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15510
Q9BQE3-356-unknown	NYQPPT...	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14916
Q9BQE3-368-unknown	LAKVQR...	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13166
Q9BQE3-408-unknown	YVGEGM...	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15511
Q9BQE3-414-unknown	EEGEFS...	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15512
Q9BQE3-432-unknown	YEEVGA...	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13167
Q9BQE3-439-unknown	SADGED...	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13168

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MPSDKT	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10511
...FFSETG	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15498
...KHVPRA	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10512
...HVPRAV	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15499
...VPRAVF	66	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15500
...RAVFVD	68	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15501
...AVFVDL	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15502
...VFVDLE	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13161
...TGTYRQ	84	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10513
...LFHPEQ	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13162
...HPEQLI	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15503
...GLQGFL	135	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14913
...QGFLVF	137	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15504
...EHSDCA	200	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14914
...EHSDCA	200	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15505
...CAFMVD	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15506
...AFMVDN	205	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13163
...MVDNEA	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13164
...ALNVDL	251	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13165
...NVDLTE	253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15507
...YHEQLT	286	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14915
...TVAEIT	291	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15508
...VPKDVN	328	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15509
...PTGFKV	352	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10514
...TGFKVG	353	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15510
...FKVGIN	355	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14916
...VPGGDL	367	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13166
...AFVHWY	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15511
...VGEGME	413	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15512
...ALEKDY	431	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13167
...EVGADS	438	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13168
...DEGEEY	448	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8292
...DEGEEY	448	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EGEEY	449	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EGEEY	449		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EGEEY	449		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EGEEY	449		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	40	SDKT.\|.TIGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	56	SETG.\|.GAGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	64	VPRA.\|.AVFV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	65	PRAV.\|.VFVD	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	66	RAVF.\|.FVDL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	68	VFVD.\|.DLEP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	70	VDLE.\|.EPTV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	84	TYRQ.\|.QLFH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	90	HPEQ.\|.QLIT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	92	EQLI.\|.ITGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	135	QGFL.\|.LVFH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	137	FLVF.\|.FHSF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	204	FMVD.\|.DNEA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	205	MVDN.\|.NEAI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	207	DNEA.\|.AIYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	251	NVDL.\|.LTEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	253	DLTE.\|.EFQT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	286	EQLT.\|.TVAE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	291	AEIT.\|.TNAC	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	328	KDVN.\|.NAAI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	352	GFKV.\|.VGIN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	353	FKVG.\|.GINY	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	355	VGIN.\|.NYQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	367	GGDL.\|.LAKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	407	VHWY.\|.YVGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	413	EGME.\|.EEGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	431	EKDY.\|.YEEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	438	GADS.\|.SADG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CBPC1_HUMAN	448	GEEY.\|.Y	inferred from experiment	unknown	MEROPS		Merops CBPC1_HUMAN -> TBA1C_HUMAN @448

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)