Q9UQR0: Sex comb on midleg-like protein 2
Protein names | - Sex comb on midleg-like protein 2 |
---|---|
Gene names | SCML2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9UQR0 |
7
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV
70 80 90 100 110 120
NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT
130 140 150 160 170 180
CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA
190 200 210 220 230 240
IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP
250 260 270 280 290 300
GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS
310 320 330 340 350 360
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY
370 380 390 400 410 420
VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG
430 440 450 460 470 480
EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH
490 500 510 520 530 540
DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL
550 560 570 580 590 600
SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF
610 620 630 640 650 660
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI
670 680 690 700
DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS
Isoforms
- Isoform 2 of Sex comb on midleg-like protein 2Sequence View
10 20 30 40 50 60
MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV
70 80 90 100 110 120
NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT
130 140 150 160 170 180
CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA
190 200 210 220 230 240
IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP
250 260 270 280 290 300
GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS
310 320 330 340 350 360
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY
370 380 390 400 410 420
VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG
430 440 450 460 470 480
EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH
490 500 510 520 530 540
DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL
550 560 570 580 590 600
SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF
610 620 630 640 650 660
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI
670 680 690 700
DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS
Protein Neighborhood
Domains & Features
7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9UQR0-1-unknown | MGQTVN... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9UQR0-2-unknown | GQTVNE... | 2 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9UQR0-2-unknown | GQTVNE... | 2 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9UQR0-2- | GQTVNE... | 2 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q9UQR0-2- | GQTVNE... | 2 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q9UQR0-2- | GQTVNE... | 2 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9UQR0-2- | GQTVNE... | 2 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q9UQR0-2- | GQTVNE... | 2 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9UQR0-9-unknown | SMDVKK... | 9 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13594 | |||
Q9UQR0-563-unknown | MYIHTS... | 563 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89051 | |||
Q9UQR0-576- | SVPGTT... | 576 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9UQR0-576-unknown | SVPGTT... | 576 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167973 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...TVNEDS | 8 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13594 | |||
...EGKYS | 700 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EGKYS | 700 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt84669 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 8 | NEDS.|.SMDV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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