Q9Y2X3: Nucleolar protein 58

General Information

Protein names	- Nucleolar protein 58 - Nucleolar protein 5
Gene names	NOP58
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y2X3

8 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF
        70         80         90        100        110        120
TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE KLNLSCIHSP VVNELMRGIR
       130        140        150        160        170        180
SQMDGLIPGV EPREMAAMCL GLAHSLSRYR LKFSADKVDT MIVQAISLLD DLDKELNNYI
       190        200        210        220        230        240
MRCREWYGWH FPELGKIISD NLTYCKCLQK VGDRKNYASA KLSELLPEEV EAEVKAAAEI
       250        260        270        280        290        300
SMGTEVSEED ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA
       310        320        330        340        350        360
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT SPKHKGKISR
       370        380        390        400        410        420
MLAAKTVLAI RYDAFGEDSS SAMGVENRAK LEARLRTLED RGIRKISGTG KALAKTEKYE
       430        440        450        460        470        480
HKSEVKTYDP SGDSTLPTCS KKRKIEQVDK EDEITEKKAK KAKIKVKVEE EEEEKVAEEE
       490        500        510        520
ETSVKKKKKR GKKKHIKEEP LSEEEPCTST AIASPEKKKK KKKKRENED

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y2X3-1-unknown	MLVLFE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2X3-79-	IVKEAH...	79		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2X3-125-	GLIPGV...	125		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y2X3-125-	GLIPGV...	125		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9Y2X3-374-unknown	AFGEDS...	374	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13608
Q9Y2X3-379-unknown	SSSAMG...	379	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13609
Q9Y2X3-434-unknown	STLPTC...	434	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13610
Q9Y2X3-444-	KIEQVD...	444		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y2X3-444-	KIEQVD...	444		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y2X3-452-unknown	DEITEK...	452	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13611

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AIRYDA	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13608
...AFGEDS	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13609
...DPSGDS	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13610
...QVDKED	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13611
...RENED	529	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	373	RYDA.\|.AFGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	378	GEDS.\|.SSSA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	433	SGDS.\|.STLP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	451	DKED.\|.DEIT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)