Q9Y3D8: Adenylate kinase isoenzyme 6 {ECO:0000255|HAMAP-Rule:MF_03173}

General Information

Protein names	- Adenylate kinase isoenzyme 6 {ECO:0000255\|HAMAP-Rule:MF_03173} - AK6 {ECO:0000255\|HAMAP-Rule:MF_03173} - 2.7.4.3 {ECO:0000255\|HAMAP-Rule:MF_03173} - Adrenal gland protein AD-004 - Coilin-interacting nuclear ATPase protein {ECO:0000255\|HAMAP-Rule:MF_03173} - hCINAP - Dual activity adenylate kinase/ATPase {ECO:0000255\|HAMAP-Rule:MF_03173} - AK/ATPase {ECO:0000255\|HAMAP-Rule:MF_03173}
Gene names	AK6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y3D8

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLPNILLTG TPGVGKTTLG KELASKSGLK YINVGDLARE EQLYDGYDEE YDCPILDEDR
        70         80         90        100        110        120
VVDELDNQMR EGGVIVDYHG CDFFPERWFH IVFVLRTDTN VLYERLETRG YNEKKLTDNI
       130        140        150        160        170
QCEIFQVLYE EATASYKEEI VHQLPSNKPE ELENNVDQIL KWIEQWIKDH NS

Isoforms

- Isoform 2 of Adenylate kinase isoenzyme 6

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q9Y3D8-1-	MLLPNI...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y3D8-1-unknown	MLLPNI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y3D8-1-unknown	MLLPNI...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y3D8-1-unknown	MLLPNI...	1		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y3D8-27-unknown	SGLKYI...	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10605
Q9Y3D8-27-unknown	SGLKYI...	27	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137130
Q9Y3D8-31-	YINVGD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y3D8-31-	YINVGD...	31		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y3D8-31-unknown	YINVGD...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173365

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELASKS	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10605
...KDHNS	172	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KDHNS	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74126

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	26	ASKS.\|.SGLK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)