Q9Y5B9: FACT complex subunit SPT16

General Information

Protein names	- FACT complex subunit SPT16 - Chromatin-specific transcription elongation factor 140 kDa subunit - FACT 140 kDa subunit - FACTp140 - Facilitates chromatin transcription complex subunit SPT16 - hSPT16
Gene names	SUPT16H
Organism	Homo sapiens
Protease Family
Protease ID	M24.974
Chromosome location
UniProt ID	Q9Y5B9

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVTLDKDAY YRRVKRLYSN WRKGEDEYAN VDAIVVSVGV DEEIVYAKST ALQTWLFGYE
        70         80         90        100        110        120
LTDTIMVFCD DKIIFMASKK KVEFLKQIAN TKGNENANGA PAITLLIREK NESNKSSFDK
       130        140        150        160        170        180
MIEAIKESKN GKKIGVFSKD KFPGEFMKSW NDCLNKEGFD KIDISAVVAY TIAVKEDGEL
       190        200        210        220        230        240
NLMKKAASIT SEVFNKFFKE RVMEIVDADE KVRHSKLAES VEKAIEEKKY LAGADPSTVE
       250        260        270        280        290        300
MCYPPIIQSG GNYNLKFSVV SDKNHMHFGA ITCAMGIRFK SYCSNLVRTL MVDPSQEVQE
       310        320        330        340        350        360
NYNFLLQLQE ELLKELRHGV KICDVYNAVM DVVKKQKPEL LNKITKNLGF GMGIEFREGS
       370        380        390        400        410        420
LVINSKNQYK LKKGMVFSIN LGFSDLTNKE GKKPEEKTYA LFIGDTVLVD EDGPATVLTS
       430        440        450        460        470        480
VKKKVKNVGI FLKNEDEEEE EEEKDEAEDL LGRGSRAALL TERTRNEMTA EEKRRAHQKE
       490        500        510        520        530        540
LAAQLNEEAK RRLTEQKGEQ QIQKARKSNV SYKNPSLMPK EPHIREMKIY IDKKYETVIM
       550        560        570        580        590        600
PVFGIATPFH IATIKNISMS VEGDYTYLRI NFYCPGSALG RNEGNIFPNP EATFVKEITY
       610        620        630        640        650        660
RASNIKAPGE QTVPALNLQN AFRIIKEVQK RYKTREAEEK EKEGIVKQDS LVINLNRSNP
       670        680        690        700        710        720
KLKDLYIRPN IAQKRMQGSL EAHVNGFRFT SVRGDKVDIL YNNIKHALFQ PCDGEMIIVL
       730        740        750        760        770        780
HFHLKNAIMF GKKRHTDVQF YTEVGEITTD LGKHQHMHDR DDLYAEQMER EMRHKLKTAF
       790        800        810        820        830        840
KNFIEKVEAL TKEELEFEVP FRDLGFNGAP YRSTCLLQPT SSALVNATEW PPFVVTLDEV
       850        860        870        880        890        900
ELIHFERVQF HLKNFDMVIV YKDYSKKVTM INAIPVASLD PIKEWLNSCD LKYTEGVQSL
       910        920        930        940        950        960
NWTKIMKTIV DDPEGFFEQG GWSFLEPEGE GSDAEEGDSE SEIEDETFNP SEDDYEEEEE
       970        980        990       1000       1010       1020
DSDEDYSSEA EESDYSKESL GSEEESGKDW DELEEEARKA DRESRYEEEE EQSRSMSRKR
      1030       1040
KASVHSSGRG SNRGSRHSSA PPKKKRK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y5B9-2-unknown	MAVTLD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y5B9-2-Acetylation	AVTLDK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y5B9-2-Acetylation	AVTLDK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y5B9-2-Acetylation	AVTLDK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y5B9-586-unknown	IFPNPE...	586		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18187
Q9Y5B9-650-unknown	SLVINL...	650		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13647
Q9Y5B9-789-unknown	ALTKEE...	789			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q9Y5B9-1006-unknown	YEEEEE...	1006		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10616

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RNEGNI	585	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18187
...IVKQDS	649	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13647
...DRESRY	1005	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10616
...KKKRK	1047	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	585	EGNI.\|.IFPN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	649	KQDS.\|.SLVI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	1005	ESRY.\|.YEEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)