O00148: ATP-dependent RNA helicase DDX39A

General Information

Protein names	- ATP-dependent RNA helicase DDX39A - 3.6.4.13 - DEAD box protein 39 - Nuclear RNA helicase URH49
Gene names	DDX39A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00148

12 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ATP-dependent RNA helicase DDX39A - Isoform 3 of ATP-dependent RNA helicase DDX39A

Sequence View

        10         20         30         40         50         60
MAEQDVENDL LDYDEEEEPQ APQESTPAPP KKDIKGSYVS IHSSGFRDFL LKPELLRAIV
        70         80         90        100        110        120
DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL ATLQQIEPVN GQVTVLVMCH
       130        140        150        160        170        180
TRELAFQISK EYERFSKYMP SVKVSVFFGG LSIKKDEEVL KKNCPHVVVG TPGRILALVR
       190        200        210        220        230        240
NRSFSLKNVK HFVLDECDKM LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKDIRPVCRK
       250        260        270        280        290        300
FMQDPMEVFV DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVI IFVKSVQRCM
       310        320        330        340        350        360
ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM DIERVNIVFN
       370        380        390        400        410        420
YDMPEDSDTY LHRVARAGRF GTKGLAITFV SDENDAKILN DVQDRFEVNV AELPEEIDIS

TYIEQSR         10         20         30         40         50         60
MAEQDVENDL LDYDEEEEPQ APQESTPAPP KKDIKGSYVS IHSSGFRDFL LKPELLRAIV
        70         80         90        100        110        120
DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL ATLQQIEPVN GQVTVLVMCH
       130        140        150        160        170        180
TRELAFQISK EYERFSKYMP SVKVSVFFGG LSIKKDEEVL KKNCPHVVVG TPGRILALVR
       190        200        210        220        230        240
NRSFSLKNVK HFVLDECDKM LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKDIRPVCRK
       250        260        270        280        290        300
FMQDPMEVFV DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVI IFVKSVQRCM
       310        320        330        340        350        360
ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM DIERVNIVFN
       370        380        390        400        410        420
YDMPEDSDTY LHRVARAGRF GTKGLAITFV SDENDAKILN DVQDRFEVNV AELPEEIDIS

TYIEQSR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00148-1-unknown	MAEQDV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73377
O00148-2-unknown	MAEQDV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00148-2-Acetylation	AEQDVE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00148-2-Acetylation	AEQDVE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O00148-2-Acetylation	AEQDVE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111320
O00148-10-unknown	LLDYDE...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174008
O00148-10-	LLDYDE...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00148-10-	LLDYDE...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00148-10-	LLDYDE...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00148-13-	YDEEEE...	13			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00148-13-unknown	YDEEEE...	13		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175247
O00148-25-unknown	STPAPP...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6979
O00148-25-unknown	STPAPP...	25		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137175
O00148-48-unknown	DFLLKP...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9874
O00148-48-unknown	DFLLKP...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139018
O00148-135-unknown	FSKYMP...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164979
O00148-135-	FSKYMP...	135			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O00148-360-	NYDMPE...	360			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00148-360-	NYDMPE...	360			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QAPQES	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6979
...QAPQES	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120086
...SSGFRD	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9874
...SSGFRD	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122087
...IEQSR	427	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	24	PQES.\|.STPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	47	GFRD.\|.DFLL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)