O14646: Chromodomain-helicase-DNA-binding protein 1

General Information

Protein names	- Chromodomain-helicase-DNA-binding protein 1 - CHD-1 - 3.6.4.12 - ATP-dependent helicase CHD1
Gene names	CHD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14646

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS DSDSGSESGS
        70         80         90        100        110        120
QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA ILKKQQQQQQ QQQHQASSNS
       130        140        150        160        170        180
GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ MSGSGSPSQS GSDSESEEER EKSSCDETES
       190        200        210        220        230        240
DYEPKNKVKS RKPQNRSKSK NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV
       250        260        270        280        290        300
SYKEDEEMKT DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD
       310        320        330        340        350        360
GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD NYKKKDQETK
       370        380        390        400        410        420
RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ KSAAGYPDYY CKWQGLPYSE
       430        440        450        460        470        480
CSWEDGALIS KKFQACIDEY FSRNQSKTTP FKDCKVLKQR PRFVALKKQP SYIGGHEGLE
       490        500        510        520        530        540
LRDYQLNGLN WLAHSWCKGN SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS
       550        560        570        580        590        600
TLTSWQREIQ TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK
       610        620        630        640        650        660
AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL KELWSLLHFI
       670        680        690        700        710        720
MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK DVEKSLPAKV EQILRMEMSA
       730        740        750        760        770        780
LQKQYYKWIL TRNYKALSKG SKGSTSGFLN IMMELKKCCN HCYLIKPPDN NEFYNKQEAL
       790        800        810        820        830        840
QHLIRSSGKL ILLDKLLIRL RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG
       850        860        870        880        890        900
ELRKQALDHF NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR
       910        920        930        940        950        960
IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT GSAPSSSTPF
       970        980        990       1000       1010       1020
NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE THENEPGPLT VGDELLSQFK
      1030       1040       1050       1060       1070       1080
VANFSNMDED DIELEPERNS KNWEEIIPED QRRRLEEEER QKELEEIYML PRMRNCAKQI
      1090       1100       1110       1120       1130       1140
SFNGSEGRRS RSRRYSGSDS DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK
      1150       1160       1170       1180       1190       1200
FGGPLERLDA IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP
      1210       1220       1230       1240       1250       1260
TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD IDWGKEDDSN
      1270       1280       1290       1300       1310       1320
LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK QLQTRADYLI KLLSRDLAKK
      1330       1340       1350       1360       1370       1380
EALSGAGSSK RRKARAKKNK AMKSIKVKEE IKSDSSPLPS EKSDEDDDKL SESKSDGRER
      1390       1400       1410       1420       1430       1440
SKKSSVSDAP VHITASGEPV PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE
      1450       1460       1470       1480       1490       1500
REQLEHTRQC LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA
      1510       1520       1530       1540       1550       1560
IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL TQYHDHHKDR
      1570       1580       1590       1600       1610       1620
HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD REKHRKLDDH RSRDHRSNLE
      1630       1640       1650       1660       1670       1680
GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD
      1690       1700       1710
QRSPYGSRSP FEHSVEHKST PEHTWSSRKT

Isoforms

- Isoform 2 of Chromodomain-helicase-DNA-binding protein 1

Sequence View

        10         20         30         40         50         60
MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS DSDSGSESGS
        70         80         90        100        110        120
QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA ILKKQQQQQQ QQQHQASSNS
       130        140        150        160        170        180
GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ MSGSGSPSQS GSDSESEEER EKSSCDETES
       190        200        210        220        230        240
DYEPKNKVKS RKPQNRSKSK NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV
       250        260        270        280        290        300
SYKEDEEMKT DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD
       310        320        330        340        350        360
GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD NYKKKDQETK
       370        380        390        400        410        420
RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ KSAAGYPDYY CKWQGLPYSE
       430        440        450        460        470        480
CSWEDGALIS KKFQACIDEY FSRNQSKTTP FKDCKVLKQR PRFVALKKQP SYIGGHEGLE
       490        500        510        520        530        540
LRDYQLNGLN WLAHSWCKGN SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS
       550        560        570        580        590        600
TLTSWQREIQ TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK
       610        620        630        640        650        660
AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL KELWSLLHFI
       670        680        690        700        710        720
MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK DVEKSLPAKV EQILRMEMSA
       730        740        750        760        770        780
LQKQYYKWIL TRNYKALSKG SKGSTSGFLN IMMELKKCCN HCYLIKPPDN NEFYNKQEAL
       790        800        810        820        830        840
QHLIRSSGKL ILLDKLLIRL RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG
       850        860        870        880        890        900
ELRKQALDHF NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR
       910        920        930        940        950        960
IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT GSAPSSSTPF
       970        980        990       1000       1010       1020
NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE THENEPGPLT VGDELLSQFK
      1030       1040       1050       1060       1070       1080
VANFSNMDED DIELEPERNS KNWEEIIPED QRRRLEEEER QKELEEIYML PRMRNCAKQI
      1090       1100       1110       1120       1130       1140
SFNGSEGRRS RSRRYSGSDS DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK
      1150       1160       1170       1180       1190       1200
FGGPLERLDA IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP
      1210       1220       1230       1240       1250       1260
TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD IDWGKEDDSN
      1270       1280       1290       1300       1310       1320
LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK QLQTRADYLI KLLSRDLAKK
      1330       1340       1350       1360       1370       1380
EALSGAGSSK RRKARAKKNK AMKSIKVKEE IKSDSSPLPS EKSDEDDDKL SESKSDGRER
      1390       1400       1410       1420       1430       1440
SKKSSVSDAP VHITASGEPV PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE
      1450       1460       1470       1480       1490       1500
REQLEHTRQC LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA
      1510       1520       1530       1540       1550       1560
IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL TQYHDHHKDR
      1570       1580       1590       1600       1610       1620
HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD REKHRKLDDH RSRDHRSNLE
      1630       1640       1650       1660       1670       1680
GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD
      1690       1700       1710
QRSPYGSRSP FEHSVEHKST PEHTWSSRKT

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14646-1-unknown	MNGHSD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14646-1-unknown	MNGHSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70507
O14646-301-unknown	GDPNAG...	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10679
O14646-301-unknown	GDPNAG...	301	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149903
O14646-1023-unknown	NFSNMD...	1023	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170750
O14646-1023-	NFSNMD...	1023		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14646-1227-unknown	SIPSDP...	1227	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170748
O14646-1227-	SIPSDP...	1227		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14646-1324-unknown	SGAGSS...	1324	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13707
O14646-1324-unknown	SGAGSS...	1324	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157935
O14646-1391-unknown	VHITAS...	1391	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170746
O14646-1391-	VHITAS...	1391		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14646-1391-	VHITAS...	1391		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14646-1391-	VHITAS...	1391		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O14646-1391-	VHITAS...	1391		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVEADG	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10679
...AVEADG	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133295
...KKEALS	1323	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13707
...KKEALS	1323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141432
...SSRKT	1710	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SSRKT	1710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66125

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	300	EADG.\|.GDPN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	1323	EALS.\|.SGAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

TopFIND

O14646: Chromodomain-helicase-DNA-binding protein 1

General Information

9

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates