O35235: Tumor necrosis factor ligand superfamily member 11

General Information

Protein names	- Tumor necrosis factor ligand superfamily member 11 - Osteoclast differentiation factor - ODF - Osteoprotegerin ligand - OPGL - Receptor activator of nuclear factor kappa-B ligand - RANKL - TNF-related activation-induced cytokine - TRANCE - CD254 - Tumor necrosis factor ligand superfamily member 11, membrane form - Tumor necrosis factor ligand superfamily member 11, soluble form
Gene names	Tnfsf11
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O35235

4 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tumor necrosis factor ligand superfamily member 11 - Isoform 3 of Tumor necrosis factor ligand superfamily member 11

Sequence View

        10         20         30         40         50         60
MRRASRDYGK YLRSSEEMGS GPGVPHEGPL HPAPSAPAPA PPPAASRSMF LALLGLGLGQ
        70         80         90        100        110        120
VVCSIALFLY FRAQMDPNRI SEDSTHCFYR ILRLHENADL QDSTLESEDT LPDSCRRMKQ
       130        140        150        160        170        180
AFQGAVQKEL QHIVGPQRFS GAPAMMEGSW LDVAQRGKPE AQPFAHLTIN AASIPSGSHK
       190        200        210        220        230        240
VTLSSWYHDR GWAKISNMTL SNGKLRVNQD GFYYLYANIC FRHHETSGSV PTDYLQLMVY
       250        260        270        280        290        300
VVKTSIKIPS SHNLMKGGST KNWSGNSEFH FYSINVGGFF KLRAGEEISI QVSNPSLLDP
       310
DQDATYFGAF KVQDID         10         20         30         40         50         60
MRRASRDYGK YLRSSEEMGS GPGVPHEGPL HPAPSAPAPA PPPAASRSMF LALLGLGLGQ
        70         80         90        100        110        120
VVCSIALFLY FRAQMDPNRI SEDSTHCFYR ILRLHENADL QDSTLESEDT LPDSCRRMKQ
       130        140        150        160        170        180
AFQGAVQKEL QHIVGPQRFS GAPAMMEGSW LDVAQRGKPE AQPFAHLTIN AASIPSGSHK
       190        200        210        220        230        240
VTLSSWYHDR GWAKISNMTL SNGKLRVNQD GFYYLYANIC FRHHETSGSV PTDYLQLMVY
       250        260        270        280        290        300
VVKTSIKIPS SHNLMKGGST KNWSGNSEFH FYSINVGGFF KLRAGEEISI QVSNPSLLDP
       310
DQDATYFGAF KVQDID

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O35235-1-unknown	MRRASR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O35235-118-unknown	MKQAFQ...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92592
O35235-118-unknown	MKQAFQ...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105738
O35235-139-unknown	FSGAPA...	139	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O35235-139-unknown	FSGAPA...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27822
O35235-139-unknown	FSGAPA...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27853
O35235-139-unknown	FSGAPA...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27859
O35235-139-unknown	FSGAPA...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115939
O35235-139-unknown	FSGAPA...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115940
O35235-146-unknown	MEGSWL...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32753
O35235-146-unknown	MEGSWL...	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137501
O35235-146-unknown	MEGSWL...	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143340

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VGPQRF	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27822
...VGPQRF	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27853
...VGPQRF	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27859
...VGPQRF	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119863
...VGPQRF	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126161
...GAPAMM	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32753
...GAPAMM	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120473
...GAPAMM	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126571
...VQDID	316	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VQDID	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88210
...VQDID	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88209

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ADA10_MOUSE	138	PQRF.\|.FSGA	inferred from experiment	unknown	MEROPS	Tanaka S	Hikita A et al.:Negative regulation of osteocla... (M12.210)	17018528,
ADA17_MOUSE	138	PQRF.\|.FSGA	inferred from experiment	unknown	MEROPS	Blobel CP	Lum L et al.:Evidence for a role of a tumor ... (M12.217)	10224132,
ADA19_MOUSE	138	PQRF.\|.FSGA	inferred from experiment	unknown	MEROPS	Blobel CP	Chesneau V et al.:Catalytic properties of ADAM19.... (M12.214)	12682046,
MMP14_MOUSE	145	PAMM.\|.MEGS	inferred from experiment	unknown	MEROPS	Tanaka S	Hikita A et al.:Negative regulation of osteocla... (M12.210)	17018528,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)