O43823: A-kinase anchor protein 8

General Information

Protein names	- A-kinase anchor protein 8 - AKAP-8 - A-kinase anchor protein 95 kDa - AKAP 95
Gene names	AKAP8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43823

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDQGYGGYGA WSAGPANTQG AYGTGVASWQ GYENYNYYGA QNTSVTTGAT YSYGPASWEA
        70         80         90        100        110        120
AKANDGGLAA GAPAMHMASY GPEPCTDNSD SLIAKINQRL DMMSKEGGRG GSGGGGEGIQ
       130        140        150        160        170        180
DRESSFRFQP FESYDSRPCL PEHNPYRPSY SYDYEFDLGS DRNGSFGGQY SECRDPARER
       190        200        210        220        230        240
GSLDGFMRGR GQGRFQDRSN PGTFMRSDPF VPPAASSEPL STPWNELNYV GGRGLGGPSP
       250        260        270        280        290        300
SRPPPSLFSQ SMAPDYGVMG MQGAGGYDST MPYGCGRSQP RMRDRDRPKR RGFDRFGPDG
       310        320        330        340        350        360
TGRKRKQFQL YEEPDTKLAR VDSEGDFSEN DDAAGDFRSG DEEFKGEDEL CDSGRQRGEK
       370        380        390        400        410        420
EDEDEDVKKR REKQRRRDRT RDRAADRIQF ACSVCKFRSF DDEEIQKHLQ SKFHKETLRF
       430        440        450        460        470        480
ISTKLPDKTV EFLQEYIVNR NKKIEKRRQE LMEKETAKPK PDPFKGIGQE HFFKKIEAAH
       490        500        510        520        530        540
CLACDMLIPA QPQLLQRHLH SVDHNHNRRL AAEQFKKTSL HVAKSVLNNR HIVKMLEKYL
       550        560        570        580        590        600
KGEDPFTSET VDPEMEGDDN LGGEDKKETP EEVAADVLAE VITAAVRAVD GEGAPAPESS
       610        620        630        640        650        660
GEPAEDEGPT DTAEAGSDPQ AEQLLEEQVP CGTAHEKGVP KARSEAAEAG NGAETMAAEA
       670        680        690
ESAQTRVAPA PAAADAEVEQ TDAESKDAVP TE

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43823-1-unknown	MDQGYG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43823-52-	SYGPAS...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43823-79-	SYGPEP...	79		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43823-262-unknown	QGAGGY...	262	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13757
O43823-339-unknown	SGDEEF...	339	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9882
O43823-577-unknown	VLAEVI...	577	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10776
O43823-657-unknown	AAEAES...	657	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13758

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVMGMQ	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13757
...AGDFRS	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9882
...EVAADV	576	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10776
...GAETMA	656	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13758
...AVPTE	692	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	261	MGMQ.\|.QGAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	338	DFRS.\|.SGDE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	576	AADV.\|.VLAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	656	ETMA.\|.AAEA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)