O60293: Zinc finger C3H1 domain-containing protein

General Information

Protein names	- Zinc finger C3H1 domain-containing protein - Coiled-coil domain-containing protein 131 - Proline/serine-rich coiled-coil protein 2
Gene names	ZFC3H1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60293

9 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS
        70         80         90        100        110        120
ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP
       130        140        150        160        170        180
SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA
       190        200        210        220        230        240
GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE
       250        260        270        280        290        300
CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
       310        320        330        340        350        360
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK
       370        380        390        400        410        420
KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA
       430        440        450        460        470        480
KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN
       490        500        510        520        530        540
QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS
       550        560        570        580        590        600
SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
       610        620        630        640        650        660
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN
       670        680        690        700        710        720
NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD
       730        740        750        760        770        780
GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL
       790        800        810        820        830        840
LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL
       850        860        870        880        890        900
MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
       910        920        930        940        950        960
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE
       970        980        990       1000       1010       1020
LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD
      1030       1040       1050       1060       1070       1080
KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP
      1090       1100       1110       1120       1130       1140
ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP
      1150       1160       1170       1180       1190       1200
CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
      1210       1220       1230       1240       1250       1260
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ
      1270       1280       1290       1300       1310       1320
MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE
      1330       1340       1350       1360       1370       1380
NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS
      1390       1400       1410       1420       1430       1440
ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF
      1450       1460       1470       1480       1490       1500
LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
      1510       1520       1530       1540       1550       1560
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV
      1570       1580       1590       1600       1610       1620
MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA
      1630       1640       1650       1660       1670       1680
AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF
      1690       1700       1710       1720       1730       1740
ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF
      1750       1760       1770       1780       1790       1800
NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
      1810       1820       1830       1840       1850       1860
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL
      1870       1880       1890       1900       1910       1920
ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG
      1930       1940       1950       1960       1970       1980
QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN

SNKTESKNH

Isoforms

- Isoform 2 of Zinc finger C3H1 domain-containing protein - Isoform 4 of Zinc finger C3H1 domain-containing protein

Sequence View

        10         20         30         40         50         60
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS
        70         80         90        100        110        120
ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP
       130        140        150        160        170        180
SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA
       190        200        210        220        230        240
GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE
       250        260        270        280        290        300
CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
       310        320        330        340        350        360
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK
       370        380        390        400        410        420
KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA
       430        440        450        460        470        480
KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN
       490        500        510        520        530        540
QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS
       550        560        570        580        590        600
SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
       610        620        630        640        650        660
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN
       670        680        690        700        710        720
NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD
       730        740        750        760        770        780
GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL
       790        800        810        820        830        840
LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL
       850        860        870        880        890        900
MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
       910        920        930        940        950        960
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE
       970        980        990       1000       1010       1020
LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD
      1030       1040       1050       1060       1070       1080
KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP
      1090       1100       1110       1120       1130       1140
ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP
      1150       1160       1170       1180       1190       1200
CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
      1210       1220       1230       1240       1250       1260
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ
      1270       1280       1290       1300       1310       1320
MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE
      1330       1340       1350       1360       1370       1380
NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS
      1390       1400       1410       1420       1430       1440
ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF
      1450       1460       1470       1480       1490       1500
LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
      1510       1520       1530       1540       1550       1560
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV
      1570       1580       1590       1600       1610       1620
MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA
      1630       1640       1650       1660       1670       1680
AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF
      1690       1700       1710       1720       1730       1740
ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF
      1750       1760       1770       1780       1790       1800
NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
      1810       1820       1830       1840       1850       1860
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL
      1870       1880       1890       1900       1910       1920
ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG
      1930       1940       1950       1960       1970       1980
QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN

SNKTESKNH         10         20         30         40         50         60
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS
        70         80         90        100        110        120
ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP
       130        140        150        160        170        180
SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA
       190        200        210        220        230        240
GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE
       250        260        270        280        290        300
CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
       310        320        330        340        350        360
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK
       370        380        390        400        410        420
KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA
       430        440        450        460        470        480
KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN
       490        500        510        520        530        540
QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS
       550        560        570        580        590        600
SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
       610        620        630        640        650        660
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN
       670        680        690        700        710        720
NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD
       730        740        750        760        770        780
GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL
       790        800        810        820        830        840
LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL
       850        860        870        880        890        900
MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
       910        920        930        940        950        960
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE
       970        980        990       1000       1010       1020
LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD
      1030       1040       1050       1060       1070       1080
KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP
      1090       1100       1110       1120       1130       1140
ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP
      1150       1160       1170       1180       1190       1200
CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
      1210       1220       1230       1240       1250       1260
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ
      1270       1280       1290       1300       1310       1320
MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE
      1330       1340       1350       1360       1370       1380
NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS
      1390       1400       1410       1420       1430       1440
ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF
      1450       1460       1470       1480       1490       1500
LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
      1510       1520       1530       1540       1550       1560
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV
      1570       1580       1590       1600       1610       1620
MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA
      1630       1640       1650       1660       1670       1680
AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF
      1690       1700       1710       1720       1730       1740
ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF
      1750       1760       1770       1780       1790       1800
NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
      1810       1820       1830       1840       1850       1860
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL
      1870       1880       1890       1900       1910       1920
ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG
      1930       1940       1950       1960       1970       1980
QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN

SNKTESKNH

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60293-1-unknown	MATADT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94998
O60293-1-unknown	MATADT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94999
O60293-2-unknown	MATADT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60293-2-Acetylation	ATADTP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60293-2-Acetylation	ATADTP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111696
O60293-2-Acetylation	ATADTP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111697
O60293-281-unknown	SSKEVA...	281		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10810
O60293-281-unknown	SSKEVA...	281		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149367
O60293-281-unknown	SSKEVA...	281		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149368
O60293-328-unknown	SLKSDT...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13760
O60293-328-unknown	SLKSDT...	328		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150491
O60293-336-	SSQGLQ...	336			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60293-336-	SSQGLQ...	336			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60293-336-unknown	SSQGLQ...	336		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1447
O60293-336-unknown	SSQGLQ...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150645
O60293-527-unknown	NYEEVA...	527		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10813
O60293-527-unknown	NYEEVA...	527		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153712
O60293-780-unknown	LLKEEI...	780		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9884
O60293-780-unknown	LLKEEI...	780		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156424

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SITKDS	280	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10810
...SITKDS	280	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132751
...SITKDS	280	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132752
...GAKPLS	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13760
...GAKPLS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133886
...GAKPLS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133887
...SDTTDS	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1447
...SDTTDS	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134043
...IYQYDN	526	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10813
...IYQYDN	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137135
...KIEYRL	779	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9884
...KIEYRL	779	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139904
...ESKNH	1989	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	280	TKDS.\|.SSKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	327	KPLS.\|.SLKS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	335	TTDS.\|.SSQG	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> ZC3H1_HUMAN @335
GRAB_HUMAN	526	QYDN.\|.NYEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	779	EYRL.\|.LLKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

TopFIND

O60293: Zinc finger C3H1 domain-containing protein

General Information

9

N-termini

6

C-termini

5

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates