O75122: CLIP-associating protein 2

General Information

Protein names	- CLIP-associating protein 2 - Cytoplasmic linker-associated protein 2 - Protein Orbit homolog 2 - hOrbit2
Gene names	CLASP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75122

13 N-termini

12 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of CLIP-associating protein 2 - Isoform 2 of CLIP-associating protein 2 - Isoform 3 of CLIP-associating protein 2

Sequence View

        10         20         30         40         50         60
MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPAN SARKPGSAGG PKVGGASKEG
        70         80         90        100        110        120
GAGAVDEDDF IKAFTDVPSI QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL
       130        140        150        160        170        180
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP
       190        200        210        220        230        240
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL
       250        260        270        280        290        300
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY
       310        320        330        340        350        360
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRPFSSKWS TANPSTVAGR VSAGSSKASS
       370        380        390        400        410        420
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RSGRLGAGAL NAGSYASLED TSDKLDGTAS
       430        440        450        460        470        480
EDGRVRAKLS APLAGMGNAK ADSRGRSRTK MVSQSQPGSR SGSPGRVLTT TALSTVSSGV
       490        500        510        520        530        540
QRVLVNSASA QKRSKIPRSQ GCSREASPSR LSVARSSRIP RPSVSQGCSR EASRESSRDT
       550        560        570        580        590        600
SPVRSFQPLA SRHHSRSTGA LYAPEVYGAS GPGYGISQSS RLSSSVSAMR VLNTGSDVEE
       610        620        630        640        650        660
AVADALKKPA RRRYESYGMH SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN
       670        680        690        700        710        720
RCASSNWSER KEGLLGLQNL LKNQRTLSRV ELKRLCEIFT RMFADPHGKR VFSMFLETLV
       730        740        750        760        770        780
DFIQVHKDDL QDWLFVLLTQ LLKKMGADLL GSVQAKVQKA LDVTRESFPN DLQFNILMRF
       790        800        810        820        830        840
TVDQTQTPSL KVKVAILKYI ETLAKQMDPG DFINSSETRL AVSRVITWTT EPKSSDVRKA
       850        860        870        880        890        900
AQSVLISLFE LNTPEFTMLL GALPKTFQDG ATKLLHNHLR NTGNGTQSSM GSPLTRPTPR
       910        920        930        940        950        960
SPANWSSPLT SPTNTSQNTL SPSAFDYDTE NMNSEDIYSS LRGVTEAIQN FSFRSQEDMN
       970        980        990       1000       1010       1020
EPLKRDSKKD DGDSMCGGPG MSDPRAGGDA TDSSQTALDN KASLLHSMPT HSSPRSRDYN
      1030       1040       1050       1060       1070       1080
PYNYSDSISP FNKSALKEAM FDDDADQFPD DLSLDHSDLV AELLKELSNH NERVEERKIA
      1090       1100       1110       1120       1130       1140
LYELMKLTQE ESFSVWDEHF KTILLLLLET LGDKEPTIRA LALKVLREIL RHQPARFKNY
      1150       1160       1170       1180       1190       1200
AELTVMKTLE AHKDPHKEVV RSAEEAASVL ATSISPEQCI KVLCPIIQTA DYPINLAAIK
      1210       1220       1230       1240       1250       1260
MQTKVIERVS KETLNLLLPE IMPGLIQGYD NSESSVRKAC VFCLVAVHAV IGDELKPHLS
      1270       1280       1290
QLTGSKMKLL NLYIKRAQTG SGGADPTTDV SGQS         10         20         30         40         50         60
MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPAN SARKPGSAGG PKVGGASKEG
        70         80         90        100        110        120
GAGAVDEDDF IKAFTDVPSI QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL
       130        140        150        160        170        180
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP
       190        200        210        220        230        240
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL
       250        260        270        280        290        300
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY
       310        320        330        340        350        360
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRPFSSKWS TANPSTVAGR VSAGSSKASS
       370        380        390        400        410        420
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RSGRLGAGAL NAGSYASLED TSDKLDGTAS
       430        440        450        460        470        480
EDGRVRAKLS APLAGMGNAK ADSRGRSRTK MVSQSQPGSR SGSPGRVLTT TALSTVSSGV
       490        500        510        520        530        540
QRVLVNSASA QKRSKIPRSQ GCSREASPSR LSVARSSRIP RPSVSQGCSR EASRESSRDT
       550        560        570        580        590        600
SPVRSFQPLA SRHHSRSTGA LYAPEVYGAS GPGYGISQSS RLSSSVSAMR VLNTGSDVEE
       610        620        630        640        650        660
AVADALKKPA RRRYESYGMH SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN
       670        680        690        700        710        720
RCASSNWSER KEGLLGLQNL LKNQRTLSRV ELKRLCEIFT RMFADPHGKR VFSMFLETLV
       730        740        750        760        770        780
DFIQVHKDDL QDWLFVLLTQ LLKKMGADLL GSVQAKVQKA LDVTRESFPN DLQFNILMRF
       790        800        810        820        830        840
TVDQTQTPSL KVKVAILKYI ETLAKQMDPG DFINSSETRL AVSRVITWTT EPKSSDVRKA
       850        860        870        880        890        900
AQSVLISLFE LNTPEFTMLL GALPKTFQDG ATKLLHNHLR NTGNGTQSSM GSPLTRPTPR
       910        920        930        940        950        960
SPANWSSPLT SPTNTSQNTL SPSAFDYDTE NMNSEDIYSS LRGVTEAIQN FSFRSQEDMN
       970        980        990       1000       1010       1020
EPLKRDSKKD DGDSMCGGPG MSDPRAGGDA TDSSQTALDN KASLLHSMPT HSSPRSRDYN
      1030       1040       1050       1060       1070       1080
PYNYSDSISP FNKSALKEAM FDDDADQFPD DLSLDHSDLV AELLKELSNH NERVEERKIA
      1090       1100       1110       1120       1130       1140
LYELMKLTQE ESFSVWDEHF KTILLLLLET LGDKEPTIRA LALKVLREIL RHQPARFKNY
      1150       1160       1170       1180       1190       1200
AELTVMKTLE AHKDPHKEVV RSAEEAASVL ATSISPEQCI KVLCPIIQTA DYPINLAAIK
      1210       1220       1230       1240       1250       1260
MQTKVIERVS KETLNLLLPE IMPGLIQGYD NSESSVRKAC VFCLVAVHAV IGDELKPHLS
      1270       1280       1290
QLTGSKMKLL NLYIKRAQTG SGGADPTTDV SGQS         10         20         30         40         50         60
MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPAN SARKPGSAGG PKVGGASKEG
        70         80         90        100        110        120
GAGAVDEDDF IKAFTDVPSI QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL
       130        140        150        160        170        180
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP
       190        200        210        220        230        240
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL
       250        260        270        280        290        300
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY
       310        320        330        340        350        360
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRPFSSKWS TANPSTVAGR VSAGSSKASS
       370        380        390        400        410        420
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RSGRLGAGAL NAGSYASLED TSDKLDGTAS
       430        440        450        460        470        480
EDGRVRAKLS APLAGMGNAK ADSRGRSRTK MVSQSQPGSR SGSPGRVLTT TALSTVSSGV
       490        500        510        520        530        540
QRVLVNSASA QKRSKIPRSQ GCSREASPSR LSVARSSRIP RPSVSQGCSR EASRESSRDT
       550        560        570        580        590        600
SPVRSFQPLA SRHHSRSTGA LYAPEVYGAS GPGYGISQSS RLSSSVSAMR VLNTGSDVEE
       610        620        630        640        650        660
AVADALKKPA RRRYESYGMH SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN
       670        680        690        700        710        720
RCASSNWSER KEGLLGLQNL LKNQRTLSRV ELKRLCEIFT RMFADPHGKR VFSMFLETLV
       730        740        750        760        770        780
DFIQVHKDDL QDWLFVLLTQ LLKKMGADLL GSVQAKVQKA LDVTRESFPN DLQFNILMRF
       790        800        810        820        830        840
TVDQTQTPSL KVKVAILKYI ETLAKQMDPG DFINSSETRL AVSRVITWTT EPKSSDVRKA
       850        860        870        880        890        900
AQSVLISLFE LNTPEFTMLL GALPKTFQDG ATKLLHNHLR NTGNGTQSSM GSPLTRPTPR
       910        920        930        940        950        960
SPANWSSPLT SPTNTSQNTL SPSAFDYDTE NMNSEDIYSS LRGVTEAIQN FSFRSQEDMN
       970        980        990       1000       1010       1020
EPLKRDSKKD DGDSMCGGPG MSDPRAGGDA TDSSQTALDN KASLLHSMPT HSSPRSRDYN
      1030       1040       1050       1060       1070       1080
PYNYSDSISP FNKSALKEAM FDDDADQFPD DLSLDHSDLV AELLKELSNH NERVEERKIA
      1090       1100       1110       1120       1130       1140
LYELMKLTQE ESFSVWDEHF KTILLLLLET LGDKEPTIRA LALKVLREIL RHQPARFKNY
      1150       1160       1170       1180       1190       1200
AELTVMKTLE AHKDPHKEVV RSAEEAASVL ATSISPEQCI KVLCPIIQTA DYPINLAAIK
      1210       1220       1230       1240       1250       1260
MQTKVIERVS KETLNLLLPE IMPGLIQGYD NSESSVRKAC VFCLVAVHAV IGDELKPHLS
      1270       1280       1290
QLTGSKMKLL NLYIKRAQTG SGGADPTTDV SGQS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 12 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75122-1-unknown	MAMGDD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75122-279-unknown	MGLRNH...	279	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000304743
O75122-279-unknown	MGLRNH...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132065
O75122-376-unknown	AAAGAK...	376	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10902
O75122-376-unknown	AAAGAK...	376	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151674
O75122-430-unknown	SAPLAG...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13784
O75122-451-	MVSQSQ...	451		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75122-483-unknown	VLVNSA...	483	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13785
O75122-498-unknown	RSQGCS...	498	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417666
O75122-593-unknown	NTGSDV...	593	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13786
O75122-605-unknown	ALKKPA...	605	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10904
O75122-618-unknown	GMHSDD...	618		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75122-947-	AIQNFS...	947		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75122-947-	AIQNFS...	947		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75122-993-	SSQTAL...	993		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75122-1007-	SMPTHS...	1007		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75122-1007-	SMPTHS...	1007		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HGAEAI	177	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418411
...HGAEAI	177	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113057
...SKSVPV	227	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418945
...SKSVPV	227	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113055
...DIDVNA	375	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10902
...DIDVNA	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135077
...VRAKLS	429	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13784
...SGVQRV	482	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13785
...AMRVLN	592	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13786
...EAVADA	604	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10904
...ASSNWS	667	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417666
...FDYDTE	929	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417386
...HNERVE	1074	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439039
...VSGQS	1294		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSGQS	1294		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VSGQS	1294	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VSGQS	1294		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSGQS	1294		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	375	DVNA.\|.AAAG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	429	AKLS.\|.SAPL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	482	VQRV.\|.VLVN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	592	RVLN.\|.NTGS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	604	VADA.\|.ALKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)