O75190: DnaJ homolog subfamily B member 6

General Information

Protein names	- DnaJ homolog subfamily B member 6 - HHDJ1 - Heat shock protein J2 - HSJ-2 - MRJ - MSJ-1
Gene names	DNAJB6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75190

6 N-termini

8 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform B of DnaJ homolog subfamily B member 6 - Isoform C of DnaJ homolog subfamily B member 6 - Isoform D of DnaJ homolog subfamily B member 6

Sequence View

        10         20         30         40         50         60
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA EAYEVLSDAK
        70         80         90        100        110        120
KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF REFFGGRDPF SFDFFEDPFE
       130        140        150        160        170        180
DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF
       190        200        210        220        230        240
GGSGMGNFKS ISTSTKMVNG RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE
       250        260        270        280        290        300
ERMRRGQNAL PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG
       310        320
LKEGGKRKKQ KQREESKKKK STKGNH         10         20         30         40         50         60
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA EAYEVLSDAK
        70         80         90        100        110        120
KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF REFFGGRDPF SFDFFEDPFE
       130        140        150        160        170        180
DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF
       190        200        210        220        230        240
GGSGMGNFKS ISTSTKMVNG RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE
       250        260        270        280        290        300
ERMRRGQNAL PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG
       310        320
LKEGGKRKKQ KQREESKKKK STKGNH         10         20         30         40         50         60
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA EAYEVLSDAK
        70         80         90        100        110        120
KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF REFFGGRDPF SFDFFEDPFE
       130        140        150        160        170        180
DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF
       190        200        210        220        230        240
GGSGMGNFKS ISTSTKMVNG RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE
       250        260        270        280        290        300
ERMRRGQNAL PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG
       310        320
LKEGGKRKKQ KQREESKKKK STKGNH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 8 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75190-1-unknown	MVDYYE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73051
O75190-1-unknown	MVDYYE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73052
O75190-1-unknown	MVDYYE...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75190-2-	VDYYEV...	2		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O75190-2-unknown	VDYYEV...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75190-2-unknown	VDYYEV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75190-2-unknown	VDYYEV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75190-2-unknown	VDYYEV...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111223
O75190-2-unknown	VDYYEV...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111224
O75190-114-unknown	FFEDPF...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10937
O75190-114-unknown	FFEDPF...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140315
O75190-114-unknown	FFEDPF...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143186
O75190-114-unknown	FFEDPF...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143187
O75190-231-unknown	GVADDD...	231	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171432
O75190-231-unknown	GVADDD...	231	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171433
O75190-231-	GVADDD...	231		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75190-231-	GVADDD...	231		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75190-231-	GVADDD...	231		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAERKF	45	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389599
...EAERKF	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153852
...EAERKF	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153853
...RDIYDK	66	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391690
...RDIYDK	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153994
...RDIYDK	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153995
...RNPDDV	98	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396240
...RNPDDV	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154340
...RNPDDV	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154341
...RNPDDV	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154342
...PFSFDF	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10937
...PFSFDF	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123437
...PFSFDF	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126412
...PFSFDF	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126413
...DFFGNR	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403407
...DFFGNR	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154683
...DFFGNR	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154684
...DFFGNR	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154685
...FSAFSG	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410643
...FSAFSG	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154907
...FSAFSG	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154908
...FSAFSG	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154909
...LKSLTI	228	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400665
...TKGNH	326	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TKGNH	326	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68671

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	113	SFDF.\|.FFED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)