O75940: Survival of motor neuron-related-splicing factor 30

General Information

Protein names	- Survival of motor neuron-related-splicing factor 30 - 30 kDa splicing factor SMNrp - SMN-related protein - Survival motor neuron domain-containing protein 1
Gene names	SMNDC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75940

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS
        70         80         90        100        110        120
SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAG YGNAEVTPLL
       130        140        150        160        170        180
NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ
       190        200        210        220        230
FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75940-1-unknown	MSEDLA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O75940-63-	SFASTQ...	63		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75940-66-unknown	STQPTH...	66	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7071
O75940-120-unknown	LNLKPV...	120	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13851
O75940-197-unknown	SIFASP...	197		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75940-197-unknown	SIFASP...	197		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75940-197-	SIFASP...	197		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75940-197-	SIFASP...	197		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O75940-197-	SIFASP...	197		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75940-197-	SIFASP...	197		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75940-197-	SIFASP...	197		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDSFAS	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7071
...EVTPLL	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13851
...HLMPQ	238	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	65	SFAS.\|.STQP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	119	TPLL.\|.LNLK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)