O94913: Pre-mRNA cleavage complex 2 protein Pcf11

General Information

Protein names	- Pre-mRNA cleavage complex 2 protein Pcf11 - Pre-mRNA cleavage complex II protein Pcf11
Gene names	PCF11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O94913

11 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEQTPAEAG AAGAREDACR DYQSSLEDLT FNSKPHINML TILAEENLPF AKEIVSLIEA
        70         80         90        100        110        120
QTAKAPSSEK LPVMYLMDSI VKNVGREYLT AFTKNLVATF ICVFEKVDEN TRKSLFKLRS
       130        140        150        160        170        180
TWDEIFPLKK LYALDVRVNS LDPAWPIKPL PPNVNTSSIH VNPKFLNKSP EEPSTPGTVV
       190        200        210        220        230        240
SSPSISTPPI VPDIQKNLTQ EQLIRQQLLA KQKQLLELQQ KKLELELEQA KAQLAVSLSV
       250        260        270        280        290        300
QQETSNLGPG SAPSKLHVSQ IPPMAVKAPH QVPVQSEKSR PGPSLQIQDL KGTNRDPRLN
       310        320        330        340        350        360
RISQHSHGKD QSHRKEFLMN TLNQSDTKTS KTIPSEKLNS SKQEKSKSGE KITKKELDQL
       370        380        390        400        410        420
DSKSKSKSKS PSPLKNKLSH TKDLKNQESE SMRLSDMNKR DPRLKKHLQD KTDGKDDDVK
       430        440        450        460        470        480
EKRKTAEKKD KDEHMKSSEH RLAGSRNKII NGIVQKQDTI TEESEKQGTK PGRSSTRKRS
       490        500        510        520        530        540
RSRSPKSRSP IIHSPKRRDR RSPKRRQRSM SPTSTPKAGK IRQSGAKQSH MEEFTPPSRE
       550        560        570        580        590        600
DRNAKRSTKQ DIRDPRRMKK TEEERPQETT NQHSTKSGTE PKENVENWQS SKSAKRWKSG
       610        620        630        640        650        660
WEENKSLQQV DEHSKPPHLR HRESWSSTKG ILSPRAPKQQ QHRLSVDANL QIPKELTLAS
       670        680        690        700        710        720
KRELLQKTSE RLASGEITQD DFLVVVHQIR QLFQYQEGVR EEQRSPFNDR FPLKRPRYED
       730        740        750        760        770        780
SDKPFVDSPA SRFAGLDTNQ RLTALAEDRP LFDGPSRPSV ARDGPTKMIF EGPNKLSPRI
       790        800        810        820        830        840
DGPPTPASLR FDGSPGQMGG GGPLRFEGPQ GQLGGGCPLR FEGPPGPVGT PLRFEGPIGQ
       850        860        870        880        890        900
AGGGGFRFEG SPGLRFEGSP GGLRFEGPGG QPVGGLRFEG HRGQPVGGLR FEGPHGQPVG
       910        920        930        940        950        960
GLRFDNPRGQ PVGGLRFEGG HGPSGAAIRF DGPHGQPGGG IRFEGPLLQQ GVGMRFEGPH
       970        980        990       1000       1010       1020
GQSVAGLRFE GQHNQLGGNL RFEGPHGQPG VGIRFEGPLV QQGGGMRFEG PSVPGGGLRI
      1030       1040       1050       1060       1070       1080
EGPLGQGGPR FEGCHALRFD GQPGQPSLLP RFDGLHGQPG PRFERTPGQP GPQRFDGPPG
      1090       1100       1110       1120       1130       1140
QQVQPRFDGV PQRFDGPQHQ QASRFDIPLG LQGTRFDNHP SQRLESVSFN QTGPYNDPPG
      1150       1160       1170       1180       1190       1200
NAFNAPSQGL QFQRHEQIFD SPQGPNFNGP HGPGNQSFSN PLNRASGHYF DEKNLQSSQF
      1210       1220       1230       1240       1250       1260
GNFGNIPAPM TVGNIQASQQ VLSGVAQPVA FGQGQQFLPV HPQNPGFVQN PSGALPKAYP
      1270       1280       1290       1300       1310       1320
DNHLSQVDVN ELFSKLLKTG ILKLSQTDSA TTQVSEVTAQ PPPEEEEDQN EDQDVPDLTN
      1330       1340       1350       1360       1370       1380
FTVEELKQRY DSVINRLYTG IQCYSCGMRF TTSQTDVYAD HLDWHYRQNR TEKDVSRKVT
      1390       1400       1410       1420       1430       1440
HRRWYYSLTD WIEFEEIADL EERAKSQFFE KVHEEVVLKT QEAAKEKEFQ SVPAGPAGAV
      1450       1460       1470       1480       1490       1500
ESCEICQEQF EQYWDEEEEE WHLKNAIRVD GKIYHPSCYE DYQNTSSFDC TPSPSKTPVE
      1510       1520       1530       1540       1550
NPLNIMLNIV KNELQEPCDS PKVKEERIDT PPACTEESIA TPSEIKTEND TVESV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O94913-2-unknown	MSEQTP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94913-2-Acetylation	SEQTPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94913-2-Acetylation	SEQTPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O94913-2-Acetylation	SEQTPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O94913-140-	SLDPAW...	140			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94913-239-	SVQQET...	239			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O94913-239-	SVQQET...	239			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94913-319-	MNTLNQ...	319			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O94913-379-unknown	SHTKDL...	379		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13856
O94913-414-unknown	GKDDDV...	414		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1507
O94913-540-unknown	EDRNAK...	540		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9918
O94913-768-	MIFEGP...	768			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O94913-768-unknown	MIFEGP...	768			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O94913-1289-	SATTQV...	1289			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O94913-1289-	SATTQV...	1289			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94913-1289-	SATTQV...	1289			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVNSLD	141	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436806
...LKNKLS	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13856
...QDKTDG	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1507
...TPPSRE	539	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9918
...IDGPPT	784	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431567
...LRFEGP	867	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434540
...FEKVHE	1413	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437076
...TVESV	1555	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	378	NKLS.\|.SHTK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	413	KTDG.\|.GKDD	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PCF11_HUMAN @413
GRAA_HUMAN	539	PSRE.\|.EDRN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)