O95433: Activator of 90 kDa heat shock protein ATPase homolog 1

General Information

Protein names	- Activator of 90 kDa heat shock protein ATPase homolog 1 - AHA1 - p38
Gene names	AHSA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95433

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE
        70         80         90        100        110        120
VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS
       130        140        150        160        170        180
VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA
       190        200        210        220        230        240
LKTEERKAKP APSKTQARPV GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA
       250        260        270        280        290        300
TLEADRGGKF HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGHFATITLT FIDKNGETEL
       310        320        330
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF

Isoforms

- Isoform 2 of Activator of 90 kDa heat shock protein ATPase homolog 1

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95433-2-unknown	MAKWGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95433-2-Acetylation	AKWGEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95433-2-Acetylation	AKWGEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O95433-19-	ATNVNN...	19			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O95433-21-	NVNNWH...	21			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O95433-136-unknown	MKEEGV...	136		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451569
O95433-170-	GESVDP...	170			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O95433-225-acetylation	VFTTQE...	225	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O95433-255-	GNVSGE...	255			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O95433-259-unknown	GEFTDL...	259		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7078

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DGNVSG	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7078
	...GARLF	338	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	258	NVSG.\|.GEFT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)