P07237: Protein disulfide-isomerase

General Information

Protein names	- Protein disulfide-isomerase - PDI - 5.3.4.1 - Cellular thyroid hormone-binding protein - Prolyl 4-hydroxylase subunit beta - p55
Gene names	P4HB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07237

7 N-termini

9 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLRRALLCLA VAALVRADAP EEEDHVLVLR KSNFAEALAA HKYLLVEFYA PWCGHCKALA
        70         80         90        100        110        120
PEYAKAAGKL KAEGSEIRLA KVDATEESDL AQQYGVRGYP TIKFFRNGDT ASPKEYTAGR
       130        140        150        160        170        180
EADDIVNWLK KRTGPAATTL PDGAAAESLV ESSEVAVIGF FKDVESDSAK QFLQAAEAID
       190        200        210        220        230        240
DIPFGITSNS DVFSKYQLDK DGVVLFKKFD EGRNNFEGEV TKENLLDFIK HNQLPLVIEF
       250        260        270        280        290        300
TEQTAPKIFG GEIKTHILLF LPKSVSDYDG KLSNFKTAAE SFKGKILFIF IDSDHTDNQR
       310        320        330        340        350        360
ILEFFGLKKE ECPAVRLITL EEEMTKYKPE SEELTAERIT EFCHRFLEGK IKPHLMSQEL
       370        380        390        400        410        420
PEDWDKQPVK VLVGKNFEDV AFDEKKNVFV EFYAPWCGHC KQLAPIWDKL GETYKDHENI
       430        440        450        460        470        480
VIAKMDSTAN EVEAVKVHSF PTLKFFPASA DRTVIDYNGE RTLDGFKKFL ESGGQDGAGD
       490        500
DDDLEDLEEA EEPDMEEDDD QKAVKDEL

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 9 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07237-18-unknown	DAPEEE...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07237-18-unknown	DAPEEE...	18		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P07237-18-	DAPEEE...	18		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P07237-18-	DAPEEE...	18		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P07237-360-unknown	LPEDWD...	360	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17160
P07237-376-	NFEDVA...	376		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07237-425-	MDSTAN...	425		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07237-427-	STANEV...	427		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07237-445-	FFPASA...	445		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SNSDVF	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460612
...EGRNNF	215	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460741
...EIKTHI	256	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461791
...SNFKTA	277	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460088
...EECPAV	314	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461362
...LEGKIK	351	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460285
...LMSQEL	359	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17160
...LEEAEE	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458300
...VKDEL	508	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	359	SQEL.\|.LPED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)