P10147: C-C motif chemokine 3

General Information

Protein names	- C-C motif chemokine 3 - G0/G1 switch regulatory protein 19-1 - Macrophage inflammatory protein 1-alpha - MIP-1-alpha - PAT 464.1 - SIS-beta - Small-inducible cytokine A3 - Tonsillar lymphocyte LD78 alpha protein - MIP-1-alpha(4-69) - LD78-alpha(4-69)
Gene names	CCL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10147

17 N-termini

16 C-termini

22 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYTSR QIPQNFIADY FETSSQCSKP
70 80 90
GVIFLTKRSR QVCADPSEEW VQKYVSDLEL SA

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

17 N-termini - 16 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P10147-9-unknown	AVLLCT...	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34959
P10147-16-unknown	ALCNQF...	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34994
P10147-16-unknown	ALCNQF...	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC35013
P10147-24-unknown	SLAADT...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10147-27-unknown	ADTPTA...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10147-36-unknown	SYTSRQ...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4799
P10147-38-unknown	TSRQIP...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4800
P10147-39-unknown	SRQIPQ...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9338
P10147-39-unknown	SRQIPQ...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27774
P10147-40-unknown	RQIPQN...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9339
P10147-40-unknown	RQIPQN...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27775
P10147-47-unknown	IADYFE...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4801
P10147-48-unknown	ADYFET...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34826
P10147-48-unknown	ADYFET...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34877
P10147-48-unknown	ADYFET...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34958
P10147-50-unknown	YFETSS...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1136
P10147-51-unknown	FETSSQ...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4802
P10147-54-unknown	SSQCSK...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9340
P10147-54-unknown	SSQCSK...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27776
P10147-64-unknown	FLTKRS...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34960
P10147-65-unknown	LTKRSR...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34995
P10147-65-unknown	LTKRSR...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC35014
P10147-76-unknown	PSEEWV...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4803
P10147-85-unknown	VSDLEL...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4804

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...STAALA	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34959
...LLCTMA	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34994
...LLCTMA	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC35013
...TACCFS	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4799
...CCFSYT	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4800
...CFSYTS	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9338
...CFSYTS	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27774
...FSYTSR	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9339
...FSYTSR	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27775
...IPQNFI	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4801
...PQNFIA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34826
...PQNFIA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34877
...PQNFIA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34958
...NFIADY	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1136
...FIADYF	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4802
...DYFETS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9340
...DYFETS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27776
...KPGVIF	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34960
...PGVIFL	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34995
...PGVIFL	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC35014
...QVCADP	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4803
...WVQKYV	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4804
...LELSA	92	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP7_HUMAN	8	AALA.\|.AVLL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	15	CTMA.\|.ALCN		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP9_HUMAN	15	CTMA.\|.ALCN		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
CATG_HUMAN	35	CCFS.\|.SYTS	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
CATG_HUMAN	37	FSYT.\|.TSRQ	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
ELNE_HUMAN	38	SYTS.\|.SRQI	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
PRTN3_HUMAN	38	SYTS.\|.SRQI	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
ELNE_HUMAN	39	YTSR.\|.RQIP	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
PRTN3_HUMAN	39	YTSR.\|.RQIP	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
CATG_HUMAN	46	QNFI.\|.IADY	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
MMP1_HUMAN	47	NFIA.\|.ADYF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP13_HUMAN	47	NFIA.\|.ADYF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	47	NFIA.\|.ADYF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
CASP1_HUMAN	49	IADY.\|.YFET	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CATG_HUMAN	50	ADYF.\|.FETS	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
ELNE_HUMAN	53	FETS.\|.SSQC	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
PRTN3_HUMAN	53	FETS.\|.SSQC	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
MMP7_HUMAN	63	GVIF.\|.FLTK		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	64	VIFL.\|.LTKR		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP9_HUMAN	64	VIFL.\|.LTKR		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
CATG_HUMAN	75	CADP.\|.PSEE	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,
CATG_HUMAN	84	QKYV.\|.VSDL	inferred from experiment	unknown	MEROPS	Hart TC	Ryu OH et al.:Proteolysis of macrophage infla... (S01.133)	15728180,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)