P10619: Lysosomal protective protein

General Information

Protein names	- Lysosomal protective protein - 3.4.16.5 - Carboxypeptidase C - Carboxypeptidase L - Cathepsin A - Protective protein cathepsin A - PPCA - Protective protein for beta-galactosidase - Lysosomal protective protein 32 kDa chain - Lysosomal protective protein 20 kDa chain
Gene names	CTSA
Organism	Homo sapiens
Protease Family	S10.002
Protease ID	S10.002
Chromosome location
UniProt ID	P10619

6 N-termini

4 C-termini

0 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY SGYLKGSGSK
        70         80         90        100        110        120
HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP FLVQPDGVTL EYNPYSWNLI
       130        140        150        160        170        180
ANVLYLESPA GVGFSYSDDK FYATNDTEVA QSNFEALQDF FRLFPEYKNN KLFLTGESYA
       190        200        210        220        230        240
GIYIPTLAVL VMQDPSMNLQ GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC
       250        260        270        280        290        300
CSQNKCNFYD NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD
       310        320        330        340        350        360
LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL NIPEQLPQWD
       370        380        390        400        410        420
MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD MACNFMGDEW FVDSLNQKME
       430        440        450        460        470        480
VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY

Isoforms

- Isoform 2 of Lysosomal protective protein

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 0 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10619-1-unknown	MIRAAP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85946
P10619-29-unknown	APDQDE...	29	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10619-29-unknown	APDQDE...	29	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt114487
P10619-158-unknown	QDFFRL...	158	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408533
P10619-158-unknown	QDFFRL...	158	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131529
P10619-298-unknown	VQDLGN...	298	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172008
P10619-298-	VQDLGN...	298		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10619-298-	VQDLGN...	298		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P10619-327-unknown	MDPPCT...	327	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10619-327-unknown	MDPPCT...	327	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116157

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PDGVTL	109	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475524
...GDKVRM	326	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GDKVRM	326	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt92399
...NKQPY	480	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...NKQPY	480	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81564
...NKQPY	480		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NKQPY	480		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...NKQPY	480		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NKQPY	480		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	42	PFHL.\|.LVIH	inferred from experiment	unknown	MEROPS	Erdos EG	Jackman HL et al.:A peptidase in human platelets ... (S10.002)	1694176,
LAMP2_HUMAN	375	DNFL.\|.LVPI	inferred from experiment	unknown	MEROPS	Dice JF	Cuervo AM et al.:Cathepsin A regulates chaperone... (S10.002)	12505983,