P17980: 26S proteasome regulatory subunit 6A

General Information

Protein names	- 26S proteasome regulatory subunit 6A - 26S proteasome AAA-ATPase subunit RPT5 - Proteasome 26S subunit ATPase 3 - Proteasome subunit P50 - Tat-binding protein 1 - TBP-1
Gene names	PSMC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17980

10 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS EIKIMKSEVL
        70         80         90        100        110        120
RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK
       130        140        150        160        170        180
CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER
       190        200        210        220        230        240
PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC
       250        260        270        280        290        300
AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK
       310        320        330        340        350        360
AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE
       370        380        390        400        410        420
ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY
       430
MEGILEVQAK KKANLQYYA

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17980-1-Acetylation	MNLLPN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17980-1-Acetylation	MNLLPN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P17980-1-Acetylation	MNLLPN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P17980-17-unknown	MATVWD...	17		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000473652
P17980-18-	ATVWDE...	18			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P17980-18-acetylation	ATVWDE...	18	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P17980-19-unknown	TVWDEA...	19		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433596
P17980-28-unknown	GIGEEV...	28			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P17980-28-	GIGEEV...	28			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P17980-316-unknown	QLDGFQ...	316		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7349
P17980-319-	GFQPNT...	319			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17980-379-unknown	VNYEEL...	379		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11271

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKAMEV	176	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435141
...AIGTKR	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431144
...AIGTKR	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432970
...LELLNQ	315	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7349
...GRLDRK	350	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433596
...NVSPDV	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11271
...LQYYA	439	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	315	LLNQ.\|.QLDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	378	SPDV.\|.VNYE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)