P20290: Transcription factor BTF3

General Information

Protein names	- Transcription factor BTF3 - Nascent polypeptide-associated complex subunit beta - NAC-beta - RNA polymerase B transcription factor 3
Gene names	BTF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20290

9 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRRTGAPAQA DSRGRGRARG GCPGGEATLS QPPPRGGTRG QEPQMKETIM NQEKLAKLQA
        70         80         90        100        110        120
QVRIGGKGTA RRKKKVVHRT ATADDKKLQF SLKKLGVNNI SGIEEVNMFT NQGTVIHFNN
       130        140        150        160        170        180
PKVQASLAAN TFTITGHAET KQLTEMLPSI LNQLGADSLT SLRRLAEALP KQSVDGKAPL
       190        200
ATGEDDDDEV PDLVENFDEA SKNEAN

Isoforms

- Isoform 2 of Transcription factor BTF3

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P20290-1-unknown	MRRTGA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20290-45-	MKETIM...	45		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P20290-45-unknown	MKETIM...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68734
P20290-45-unknown	MKETIM...	45	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P20290-47-unknown	ETIMNQ...	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11324
P20290-47-unknown	ETIMNQ...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196060
P20290-64-unknown	IGGKGT...	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10023
P20290-64-unknown	IGGKGT...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136835
P20290-165-unknown	LAEALP...	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164812
P20290-165-	LAEALP...	165		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P20290-176-unknown	GKAPLA...	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1685
P20290-176-unknown	GKAPLA...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143972
P20290-176-	GKAPLA...	176		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P20290-176-	GKAPLA...	176		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20290-176-	GKAPLA...	176		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EPQMKE	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11324
...QAQVRI	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10023
...KQSVDG	175	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1685
...KQSVDG	175	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127215
...KNEAN	206		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KNEAN	206	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KNEAN	206	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt64352
...KNEAN	206		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	46	QMKE.\|.ETIM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	63	QVRI.\|.IGGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CASP3_HUMAN	175	SVDG.\|.GKAP	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)