P22087: rRNA 2'-O-methyltransferase fibrillarin

General Information

Protein names	- rRNA 2'-O-methyltransferase fibrillarin - 2.1.1.- - 34 kDa nucleolar scleroderma antigen - Histone-glutamine methyltransferase
Gene names	FBL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22087

9 N-termini

11 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKPGFSPRGG GFGGRGGFGD RGGRGGRGGF GGGRGRGGGF RGRGRGGGGG GGGGGGGGRG
        70         80         90        100        110        120
GGGFHSGGNR GRGRGGKRGN QSGKNVMVEP HRHEGVFICR GKEDALVTKN LVPGESVYGE
       130        140        150        160        170        180
KRVSISEGDD KIEYRAWNPF RSKLAAAILG GVDQIHIKPG AKVLYLGAAS GTTVSHVSDI
       190        200        210        220        230        240
VGPDGLVYAV EFSHRSGRDL INLAKKRTNI IPVIEDARHP HKYRMLIAMV DVIFADVAQP
       250        260        270        280        290        300
DQTRIVALNA HTFLRNGGHF VISIKANCID STASAEAVFA SEVKKMQQEN MKPQEQLTLE
       310        320
PYERDHAVVV GVYRPPPKVK N

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 11 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22087-1-unknown	MKPGFS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22087-86-unknown	VMVEPH...	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472419
P22087-105-unknown	ALVTKN...	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11337
P22087-110-	NLVPGE...	110		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22087-123-	VSISEG...	123		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22087-124-	SISEGD...	124		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22087-124-	SISEGD...	124		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P22087-148-unknown	ILGGVD...	148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3685
P22087-168-	AASGTT...	168		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22087-185-unknown	GLVYAV...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11338

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RGKEDA	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11337
...KLAAAI	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3685
...LGAASG	170	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472805
...DIVGPD	183	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472433
...IVGPDG	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11338
...VYAVEF	191	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471867
...VISIKA	265	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471350
...PQEQLT	297	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472726
...YERDHA	306	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469249
...VGVYRP	314	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472419
...PKVKN	321	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	104	KEDA.\|.ALVT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATB_HUMAN	147	AAAI.\|.ILGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	184	GPDG.\|.GLVY	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)