TopFIND 4.0

P26350: Prothymosin alpha

General Information

Protein names	- Prothymosin alpha - Prothymosin alpha, N-terminally processed - Thymosin alpha
Gene names	Ptma
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P26350

11

N-termini

4

C-termini

3

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD NEVDEEEEEG
70 80 90 100 110
GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV DTKKQKTEED D

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26350-1-Acetylation	MSDAAV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26350-2-Acetylation	SDAAVD...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P26350-2-Acetylation	SDAAVD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26350-2-Acetylation	SDAAVD...	2	acetylation-		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P26350-2-Acetylation	SDAAVD...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P26350-8-unknown	TSSEIT...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32330
P26350-8-unmodified	TSSEIT...	8			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26350-14-unmodified	TKDLKE...	14			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26350-17-unmodified	LKEKKE...	17			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26350-69-unknown	EGDGEE...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28353
P26350-75-unmodified	EDGDED...	75			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26350-77-unknown	GDEDEE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32331
P26350-79-unmodified	EDEEAE...	79			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26350-80-unmodified	DEEAEA...	80			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DAAVDT	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32330
	...EEEEEE	68	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28353
	...GEEEDG	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32331
	...TEEDD	111	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	7	AVDT.\|.TSSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_MOUSE	68	EEEE.\|.EGDG	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
GRAB_MOUSE	76	EEDG.\|.GDED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)