P30041: Peroxiredoxin-6

General Information

Protein names	- Peroxiredoxin-6 - 1.11.1.15 {ECO:0000269\|PubMed:10893423, ECO:0000269\|PubMed:9497358} - 1-Cys peroxiredoxin - 1-Cys PRX - 24 kDa protein - Acidic calcium-independent phospholipase A2 - aiPLA2 - 3.1.1.4 {ECO:0000269\|PubMed:10893423} - Antioxidant protein 2 - Liver 2D page spot 40 - Non-selenium glutathione peroxidase - NSGPx - Red blood cells page spot 12
Gene names	PRDX6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30041

20 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE
        70         80         90        100        110        120
FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA
       130        140        150        160        170        180
EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD
       190        200        210        220
WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

20 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30041-1-unknown	MPGGLL...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30041-2-unknown	PGGLLL...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30041-2-unknown	PGGLLL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30041-2-unknown	PGGLLL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30041-2-unmodified	PGGLLL...	2			other		CNRS/ISV	Large_scale_NTA_Human
P30041-2-acetylation	PGGLLL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-3-	GGLLLG...	3			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P30041-4-	GLLLGD...	4			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P30041-8-unknown	GDVAPN...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3758
P30041-9-unknown	DVAPNF...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7408
P30041-39-acetylation	HPRDFT...	39	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-42-	DFTPVC...	42			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-42-acetylation	DFTPVC...	42	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-54-	AAKLAP...	54			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-72-	SIDSVE...	72			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30041-86-acetylation	INAYNC...	86	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-93-unknown	EPTEKL...	93		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17556
P30041-95-unknown	TEKLPF...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17557
P30041-109-acetylation	ELAILL...	109	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-110-	LAILLG...	110			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30041-189-unknown	VLPTIP...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17558
P30041-190-unknown	LPTIPE...	190		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7409

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGLLLG	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3758
...GLLLGD	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7408
...AYNCEE	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17556
...NCEEPT	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17557
...GDSVMV	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17558
...DSVMVL	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7409
...YTPQP	224	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	7	LLLG.\|.GDVA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	8	LLGD.\|.DVAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	92	NCEE.\|.EPTE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	94	EEPT.\|.TEKL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	188	SVMV.\|.VLPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	189	VMVL.\|.LPTI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)