P35251: Replication factor C subunit 1

General Information

Protein names	- Replication factor C subunit 1 - Activator 1 140 kDa subunit - A1 140 kDa subunit - Activator 1 large subunit - Activator 1 subunit 1 - DNA-binding protein PO-GA - Replication factor C 140 kDa subunit - RF-C 140 kDa subunit - RFC140 - Replication factor C large subunit
Gene names	RFC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35251

15 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDIRKFFGVI PSGKKLVSET VKKNEKTKSD EETLKAKKGI KEIKVNSSRK EDDFKQKQPS
        70         80         90        100        110        120
KKKRIIYDSD SESEETLQVK NAKKPPEKLP VSSKPGKISR QDPVTYISET DEEDDFMCKK
       130        140        150        160        170        180
AASKSKENGR STNSHLGTSN MKKNEENTKT KNKPLSPIKL TPTSVLDYFG TGSVQRSNKK
       190        200        210        220        230        240
MVASKRKELS QNTDESGLND EAIAKQLQLD EDAELERQLH EDEEFARTLA MLDEEPKTKK
       250        260        270        280        290        300
ARKDTEAGET FSSVQANLSK AEKHKYPHKV KTAQVSDERK SYSPRKQSKY ESSKESQQHS
       310        320        330        340        350        360
KSSADKIGEV SSPKASSKLA IMKRKEESSY KEIEPVASKR KENAIKLKGE TKTPKKTKSS
       370        380        390        400        410        420
PAKKESVSPE DSEKKRTNYQ AYRSYLNREG PKALGSKEIP KGAENCLEGL IFVITGVLES
       430        440        450        460        470        480
IERDEAKSLI ERYGGKVTGN VSKKTNYLVM GRDSGQSKSD KAAALGTKII DEDGLLNLIR
       490        500        510        520        530        540
TMPGKKSKYE IAVETEMKKE SKLERTPQKN VQGKRKISPS KKESESKKSR PTSKRDSLAK
       550        560        570        580        590        600
TIKKETDVFW KSLDFKEQVA EETSGDSKAR NLADDSSENK VENLLWVDKY KPTSLKTIIG
       610        620        630        640        650        660
QQGDQSCANK LLRWLRNWQK SSSEDKKHAA KFGKFSGKDD GSSFKAALLS GPPGVGKTTT
       670        680        690        700        710        720
ASLVCQELGY SYVELNASDT RSKSSLKAIV AESLNNTSIK GFYSNGAASS VSTKHALIMD
       730        740        750        760        770        780
EVDGMAGNED RGGIQELIGL IKHTKIPIIC MCNDRNHPKI RSLVHYCFDL RFQRPRVEQI
       790        800        810        820        830        840
KGAMMSIAFK EGLKIPPPAM NEIILGANQD IRQVLHNLSM WCARSKALTY DQAKADSHRA
       850        860        870        880        890        900
KKDIKMGPFD VARKVFAAGE ETAHMSLVDK SDLFFHDYSI APLFVQENYI HVKPVAAGGD
       910        920        930        940        950        960
MKKHLMLLSR AADSICDGDL VDSQIRSKQN WSLLPAQAIY ASVLPGELMR GYMTQFPTFP
       970        980        990       1000       1010       1020
SWLGKHSSTG KHDRIVQDLA LHMSLRTYSS KRTVNMDYLS LLRDALVQPL TSQGVDGVQD
      1030       1040       1050       1060       1070       1080
VVALMDTYYL MKEDFENIME ISSWGGKPSP FSKLDPKVKA AFTRAYNKEA HLTPYSLQAI
      1090       1100       1110       1120       1130       1140
KASRHSTSPS LDSEYNEELN EDDSQSDEKD QDAIETDAMI KKKTKSSKPS KPEKDKEPRK

GKGKSSKK

Isoforms

- Isoform 2 of Replication factor C subunit 1

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

15 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35251-1-unknown	MDIRKF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35251-1-unknown	MDIRKF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87328
P35251-168-	YFGTGS...	168		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P35251-168-unknown	YFGTGS...	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165380
P35251-252-unknown	SSVQAN...	252		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P35251-252-unknown	SSVQAN...	252	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160105
P35251-252-	SSVQAN...	252		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P35251-552-	SLDFKE...	552		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35251-552-unknown	SLDFKE...	552	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170588
P35251-646-unknown	AALLSG...	646	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176579
P35251-646-	AALLSG...	646		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P35251-646-	AALLSG...	646		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P35251-718-unknown	IMDEVD...	718	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14090
P35251-718-unknown	IMDEVD...	718	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156001
P35251-724-	GMAGNE...	724		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P35251-724-	GMAGNE...	724		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35251-724-	GMAGNE...	724		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P35251-724-	GMAGNE...	724		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P35251-724-unknown	GMAGNE...	724	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1790
P35251-724-unknown	GMAGNE...	724	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156099
P35251-923-unknown	SQIRSK...	923	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1792
P35251-923-unknown	SQIRSK...	923	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156970
P35251-1118-unknown	AMIKKK...	1118	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1794
P35251-1118-unknown	AMIKKK...	1118	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157432
P35251-1134-unknown	KDKEPR...	1134	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11454
P35251-1134-unknown	KDKEPR...	1134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157478

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TKHALI	717	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14090
...TKHALI	717	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139461
...MDEVDG	723	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1790
...MDEVDG	723	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139562
...GDLVDS	922	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1792
...GDLVDS	922	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140461
...AIETDA	1117	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1794
...AIETDA	1117	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140930
...PSKPEK	1133	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11454
...PSKPEK	1133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140976
...KSSKK	1148	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KSSKK	1148	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82946
...KSSKK	1148		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KSSKK	1148		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KSSKK	1148		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KSSKK	1148		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	717	HALI.\|.IMDE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	723	EVDG.\|.GMAG	inferred from experiment	unknown	MEROPS	Denis F	Rheaume E et al.:The large subunit of replicatio... (C14.003)	9351817,
CASP3_HUMAN	922	LVDS.\|.SQIR	inferred from experiment	unknown	MEROPS	Denis F	Rheaume E et al.:The large subunit of replicatio... (C14.003)	9351817,
CASP3_HUMAN	1117	ETDA.\|.AMIK	inferred from experiment	unknown	MEROPS	Denis F	Rheaume E et al.:The large subunit of replicatio... (C14.003)	9351817,
GRAB_HUMAN	1133	KPEK.\|.KDKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)