TopFIND 4.0

P41567: Eukaryotic translation initiation factor 1

General Information

Protein names	- Eukaryotic translation initiation factor 1 - eIF1 - A121 - Protein translation factor SUI1 homolog - Sui1iso1
Gene names	EIF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P41567

11

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
70 80 90 100 110
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

11 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P41567-2-unknown	MSAIQN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41567-2-Acetylation	SAIQNL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41567-7-	LHSFDP...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41567-8-	HSFDPF...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41567-9-unknown	SFDPFA...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14121
P41567-9-	SFDPFA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P41567-9-	SFDPFA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41567-9-	SFDPFA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P41567-9-	SFDPFA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P41567-9-	SFDPFA...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P41567-16-	ASKGDD...	16			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41567-17-	SKGDDL...	17			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41567-20-unknown	DDLLPA...	20		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P41567-47-unknown	VQGIAD...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3798
P41567-53-unknown	DYDKKK...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467918

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...IQNLHS	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14121
	...KTLTTV	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3798
	...KVHGF	113	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	8	NLHS.\|.SFDP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	46	LTTV.\|.VQGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)