P43686: 26S proteasome regulatory subunit 6B
Protein names | - 26S proteasome regulatory subunit 6B - 26S proteasome AAA-ATPase subunit RPT3 - MB67-interacting protein - MIP224 - Proteasome 26S subunit ATPase 4 - Tat-binding protein 7 - TBP-7 |
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Gene names | PSMC4 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P43686 |
10
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY
70 80 90 100 110 120
IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID
130 140 150 160 170 180
RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA
190 200 210 220 230 240
VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL
250 260 270 280 290 300
GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD
310 320 330 340 350 360
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL
370 380 390 400 410
EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK
Isoforms
- Isoform 2 of 26S protease regulatory subunit 6B - Isoform 2 of 26S proteasome regulatory subunit 6BSequence View
10 20 30 40 50 60
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY
70 80 90 100 110 120
IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID
130 140 150 160 170 180
RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA
190 200 210 220 230 240
VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL
250 260 270 280 290 300
GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD
310 320 330 340 350 360
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL
370 380 390 400 410
EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK
10 20 30 40 50 60
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY
70 80 90 100 110 120
IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID
130 140 150 160 170 180
RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA
190 200 210 220 230 240
VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL
250 260 270 280 290 300
GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD
310 320 330 340 350 360
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL
370 380 390 400 410
EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK
Protein Neighborhood
Domains & Features
10 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P43686-1-unknown | MEEIGI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86320 | |||
P43686-1-Acetylation | MEEIGI... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P43686-1-Acetylation | MEEIGI... | 1 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P43686-1-Acetylation | MEEIGI... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P43686-1-Acetylation | MEEIGI... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt102832 | ||
P43686-28-unknown | SFLGPE... | 28 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14131 | |||
P43686-56-unknown | VQEEYI... | 56 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7469 | |||
P43686-153- | MLTSDQ... | 153 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P43686-153-unknown | MLTSDQ... | 153 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175701 | |||
P43686-167-unknown | IGGMDI... | 167 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11521 | |||
P43686-167-unknown | IGGMDI... | 167 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144096 | |||
P43686-295-unknown | QMDGFD... | 295 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7470 | |||
P43686-295-unknown | QMDGFD... | 295 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148946 | |||
P43686-298- | GFDQNV... | 298 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P43686-298- | GFDQNV... | 298 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P43686-298- | GFDQNV... | 298 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P43686-298- | GFDQNV... | 298 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
P43686-298-unknown | GFDQNV... | 298 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165989 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PQTGLS | 27 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14131 | |||
...PQTGLS | 27 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120341 | |||
...LEFLEV | 55 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7469 | |||
...VMYADI | 166 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11521 | |||
...VMYADI | 166 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127347 | |||
...LELLNQ | 294 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7470 | |||
...LELLNQ | 294 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132327 | |||
...HEFYK | 418 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...HEFYK | 418 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81938 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 27 | TGLS.|.SFLG | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
CATS_HUMAN | 55 | FLEV.|.VQEE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
GRAB_HUMAN | 166 | YADI.|.IGGM | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
CATS_HUMAN | 294 | LLNQ.|.QMDG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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