P46087: Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

General Information

Protein names	- Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase - 2.1.1.- {ECO:0000305\|PubMed:23913415} - Nucleolar protein 1 - Nucleolar protein 2 homolog - Proliferating-cell nucleolar antigen p120 - Proliferation-associated nucleolar protein p120
Gene names	NOP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46087

11 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Putative ribosomal RNA methyltransferase NOP2 - Isoform 3 of Putative ribosomal RNA methyltransferase NOP2 - Isoform 4 of Putative ribosomal RNA methyltransferase NOP2 - Isoform 2 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase - Isoform 3 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase - Isoform 4 of Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

Sequence View

        10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS         10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS         10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS         10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS         10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS         10         20         30         40         50         60
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
        70         80         90        100        110        120
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
       130        140        150        160        170        180
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
       190        200        210        220        230        240
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
       250        260        270        280        290        300
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
       310        320        330        340        350        360
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
       370        380        390        400        410        420
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
       430        440        450        460        470        480
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
       490        500        510        520        530        540
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
       550        560        570        580        590        600
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
       610        620        630        640        650        660
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
       670        680        690        700        710        720
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
       730        740        750        760        770        780
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
       790        800        810
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46087-1-unknown	MGRKLD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46087-1-unknown	MGRKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83040
P46087-1-unknown	MGRKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83041
P46087-1-unknown	MGRKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83042
P46087-70-unknown	AKPLPG...	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17659
P46087-70-unknown	AKPLPG...	70	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140675
P46087-92-unknown	KGPQSL...	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10086
P46087-92-unknown	KGPQSL...	92	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141938
P46087-92-unknown	KGPQSL...	92	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196820
P46087-92-unknown	KGPQSL...	92	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196821
P46087-208-	GGLQIN...	208		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46087-208-	GGLQIN...	208		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46087-208-	GGLQIN...	208		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P46087-208-	GGLQIN...	208		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P46087-208-	GGLQIN...	208		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P46087-208-unknown	GGLQIN...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167816
P46087-208-unknown	GGLQIN...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167817
P46087-208-unknown	GGLQIN...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167815
P46087-220-unknown	VLPPAG...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169629
P46087-220-unknown	VLPPAG...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169630
P46087-220-unknown	VLPPAG...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169628
P46087-220-	VLPPAG...	220		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P46087-590-	SIPQSQ...	590		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46087-590-unknown	SIPQSQ...	590	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170499
P46087-590-unknown	SIPQSQ...	590	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170498
P46087-768-unknown	AAFQKQ...	768	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169626
P46087-768-unknown	AAFQKQ...	768	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169625
P46087-768-	AAFQKQ...	768		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...NKSPEA	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17659
...NKSPEA	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123810
...NKSPEA	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123811
...NKSPEA	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123812
...QTAGKK	91	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10086
...QTAGKK	91	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125119
...QLLLS	812	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QLLLS	812	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt78658
...QLLLS	812	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt78660
...QLLLS	812		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QLLLS	812		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	69	SPEA.\|.AKPL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	91	AGKK.\|.KGPQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)