P47897: Glutamine--tRNA ligase

General Information

Protein names	- Glutamine--tRNA ligase - 6.1.1.18 {ECO:0000269\|PubMed:24656866, ECO:0000269\|PubMed:26869582} - Glutaminyl-tRNA synthetase - GlnRS {ECO:0000303\|PubMed:25288775, ECO:0000303\|PubMed:26869582}
Gene names	QARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P47897

7 N-termini

7 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK ATGILLYGLA
        70         80         90        100        110        120
SRLRDTRRLS FLVSYIASKK IHTEPQLSAA LEYVRSHPLD PIDTVDFERE CGVGVIVTPE
       130        140        150        160        170        180
QIEEAVEAAI NRHRPQLLVE RYHFNMGLLM GEARAVLKWA DGKMIKNEVD MQVLHLLGPK
       190        200        210        220        230        240
LEADLEKKFK VAKARLEETD RRTAKDVVEN GETADQTLSL MEQLRGEALK FHKPGENYKT
       250        260        270        280        290        300
PGYVVTPHTM NLLKQHLEIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL
       310        320        330        340        350        360
RFDDTNPEKE EAKFFTAICD MVAWLGYTPY KVTYASDYFD QLYAWAVELI RRGLAYVCHQ
       370        380        390        400        410        420
RGEELKGHNT LPSPWRDRPM EESLLLFEAM RKGKFSEGEA TLRMKLVMED GKMDPVAYRV
       430        440        450        460        470        480
KYTPHHRTGD KWCIYPTYDY THCLCDSIEH ITHSLCTKEF QARRSSYFWL CNALDVYCPV
       490        500        510        520        530        540
QWEYGRLNLH YAVVSKRKIL QLVATGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG
       550        560        570        580        590        600
VTVAQTTMEP HLLEACVRDV LNDTAPRAMA VLESLRVIIT NFPAAKSLDI QVPNFPADET
       610        620        630        640        650        660
KGFHQVPFAP IVFIERTDFK EEPEPGFKRL AWGQPVGLRH TGYVIELQHV VKGPSGCVES
       670        680        690        700        710        720
LEVTCRRADA GEKPKAFIHW VSQPLMCEVR LYERLFQHKN PEDPTEVPGG FLSDLNLASL
       730        740        750        760        770
HVVDAALVDC SVALAKPFDK FQFERLGYFS VDPDSHQGKL VFNRTVTLKE DPGKV

Isoforms

- Isoform 2 of Glutamine--tRNA ligase

Sequence View

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Evidence Codes:

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Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P47897-2-unknown	MAALDS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P47897-2-Acetylation	AALDSL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P47897-2-Acetylation	AALDSL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P47897-2-Acetylation	AALDSL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P47897-2-Acetylation	AALDSL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P47897-22-unknown	ETLKNS...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11549
P47897-47-unknown	TIDKAT...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14142
P47897-96-	SHPLDP...	96			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P47897-185-unknown	LEKKFK...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11550
P47897-481-unknown	QWEYGR...	481		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396326

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EQKARE	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11549
...QTLGST	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14142
...KLEADL	184	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11550
...ITGGQV	263	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392850
...EDPGKV	774	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8229
...DPGKV	775	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DPGKV	775		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DPGKV	775		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DPGKV	775		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DPGKV	775		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	21	KARE.\|.ETLK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	46	LGST.\|.TIDK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	184	EADL.\|.LEKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CBPA4_HUMAN	774	PGKV.\|.V	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)